About the Authors

Gülin Güler-Gane

Affiliation Department of Antibody Discovery and Protein Engineering, MedImmune Ltd., Granta Park, Cambridge, United Kingdom

Sara Kidd

Affiliation Department of Antibody Discovery and Protein Engineering, MedImmune Ltd., Granta Park, Cambridge, United Kingdom

Sudharsan Sridharan

Affiliation Department of Antibody Discovery and Protein Engineering, MedImmune Ltd., Granta Park, Cambridge, United Kingdom

Tristan J. Vaughan

Affiliation Department of Antibody Discovery and Protein Engineering, MedImmune Ltd., Granta Park, Cambridge, United Kingdom

Trevor C. I. Wilkinson

Affiliation Department of Antibody Discovery and Protein Engineering, MedImmune Ltd., Granta Park, Cambridge, United Kingdom

Natalie J. Tigue

tiguen@medimmune.com

Affiliation Department of Antibody Discovery and Protein Engineering, MedImmune Ltd., Granta Park, Cambridge, United Kingdom

Competing Interests

All authors are employees of MedImmune Ltd (a member of the AstraZeneca Group) and had stock or stock options in AstraZeneca, the parent company of MedImmune. This does not alter our adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: NT GG. Performed the experiments: GG SK NT. Analyzed the data: GG NT. Contributed reagents/materials/analysis tools: GG SK SS. Wrote the paper: NT GG SK SS TV TW.