Potency of Full- Length MGF to Induce Maximal Activation of the IGF-I R Is Similar to Recombinant Human IGF-I at High Equimolar Concentrations

Joseph A. M. J. L. Janssen; Leo J. Hofland; Christian J. Strasburger; Elisabeth S. R. van den Dungen; Mario Thevis

doi:10.1371/journal.pone.0150453

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Open Access

Peer-reviewed

Research Article

Potency of Full- Length MGF to Induce Maximal Activation of the IGF-I R Is Similar to Recombinant Human IGF-I at High Equimolar Concentrations

Joseph A. M. J. L. Janssen ,

* E-mail: j.a.m.j.l.janssen@erasmusmc.nl

Affiliation Department of Internal Medicine, Division of Endocrinology, Erasmus MC, Rotterdam, the Netherlands
⨯
Leo J. Hofland,

Affiliation Department of Internal Medicine, Division of Endocrinology, Erasmus MC, Rotterdam, the Netherlands
⨯
Christian J. Strasburger,

Affiliation Department of Medicine for Endocrinology, Diabetes and Nutritional Medicine Charité Universitätsmedizin, Berlin, Germany
⨯
Elisabeth S. R. van den Dungen,

Affiliation Department of Internal Medicine, Division of Endocrinology, Erasmus MC, Rotterdam, the Netherlands
⨯
Mario Thevis

Affiliation Center for Preventive Doping Research – Institute of Biochemistry, German Sport University Cologne, Cologne, Germany
⨯

Potency of Full- Length MGF to Induce Maximal Activation of the IGF-I R Is Similar to Recombinant Human IGF-I at High Equimolar Concentrations

Joseph A. M. J. L. Janssen,
Leo J. Hofland,
Christian J. Strasburger,
Elisabeth S. R. van den Dungen,
Mario Thevis

Published: March 18, 2016
https://doi.org/10.1371/journal.pone.0150453

About the Authors

Joseph A. M. J. L. Janssen

* E-mail: j.a.m.j.l.janssen@erasmusmc.nl

Affiliation Department of Internal Medicine, Division of Endocrinology, Erasmus MC, Rotterdam, the Netherlands

Leo J. Hofland

Affiliation Department of Internal Medicine, Division of Endocrinology, Erasmus MC, Rotterdam, the Netherlands

Christian J. Strasburger

Affiliation Department of Medicine for Endocrinology, Diabetes and Nutritional Medicine Charité Universitätsmedizin, Berlin, Germany

Elisabeth S. R. van den Dungen

Affiliation Department of Internal Medicine, Division of Endocrinology, Erasmus MC, Rotterdam, the Netherlands

Mario Thevis

Affiliation Center for Preventive Doping Research – Institute of Biochemistry, German Sport University Cologne, Cologne, Germany

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JAMJLJ LJH CJS ESRD MT. Performed the experiments: JAMJLJ LJH ESRD. Analyzed the data: JAMJLJ LJH ESRD. Contributed reagents/materials/analysis tools: JAMJLJ LJH ESRD MT. Wrote the paper: JAMJL LJH CJS ESRD MT.

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Insulin
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Mechano growth factor
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Skeletal muscles
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Insulin-like growth factors
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Signal to noise ratio
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Muscle biochemistry
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Phosphorylation
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Growth factors
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