About the Authors

Kazutoshi Fujibayashi

Contributed equally to this work with: Kazutoshi Fujibayashi, Toshiaki Gunji

kfujiba@juntendo.ac.jp

Affiliation Department of General Medicine, School of Medicine, Juntendo University, Tokyo, Japan

Toshiaki Gunji

Contributed equally to this work with: Kazutoshi Fujibayashi, Toshiaki Gunji

Affiliation Center for Preventive Medicine, NTT Medical Center Tokyo, Tokyo, Japan

Hirohide Yokokawa

‡ These authors also contributed equally to this work.

Affiliation Department of General Medicine, School of Medicine, Juntendo University, Tokyo, Japan

Toshio Naito

Affiliation Department of General Medicine, School of Medicine, Juntendo University, Tokyo, Japan

Noriko Sasabe

Affiliation Center for Preventive Medicine, NTT Medical Center Tokyo, Tokyo, Japan

Mitsue Okumura

Affiliation Center for Preventive Medicine, NTT Medical Center Tokyo, Tokyo, Japan

Kimiko Iijima

Affiliation Center for Preventive Medicine, NTT Medical Center Tokyo, Tokyo, Japan

Katsuhiko Shibuya

Affiliation Department of General Medicine, School of Medicine, Juntendo University, Tokyo, Japan

Teruhiko Hisaoka

Affiliation Department of General Medicine, School of Medicine, Juntendo University, Tokyo, Japan

Hiroshi Fukuda

‡ These authors also contributed equally to this work.

Affiliation Department of General Medicine, School of Medicine, Juntendo University, Tokyo, Japan

Competing Interests

The authors of this manuscript have read the journal's policy and have the following competing interests: KF: Employment, NTT Medical Center Tokyo. TG: Employment, NTT Medical Center Tokyo. NS: Employment, NTT Medical Center Tokyo. MO: Employment, NTT Medical Center Tokyo. KI: Employment, NTT Medical Center Tokyo. This does not alter the author's adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: KF TG HY TN TH HF. Performed the experiments: KF TG NS MO KI. Analyzed the data: KF TG HY KS. Contributed reagents/materials/analysis tools: KF TG NS MO KI. Wrote the paper: KF TG HY.