About the Authors

Arlene M. Gallagher

arlene.gallagher@cprd.com

Affiliations Clinical Practice Research Datalink, Medicines and Healthcare products Regulatory Agency, London, United Kingdom, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands

Tim Williams

Affiliation Clinical Practice Research Datalink, Medicines and Healthcare products Regulatory Agency, London, United Kingdom

Hubert G. M. Leufkens

Affiliation Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands

Frank de Vries

Affiliation Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AMG FDV. Performed the experiments: AMG. Analyzed the data: AMG. Wrote the paper: AMG FDV TW HGML. Advisor throughout study: HGML.