About the Authors

Xu-Ping Xu

Affiliation Institute of Antibody Engineering, School of Biotechnology, Southern Medical University, Guangzhou, China

Hai-Yan Gan

Affiliation Guangzhou Darui Biotechnology Co. LTD, Guangzhou, China

Fen-Xia Li

Affiliation Guangzhou Darui Biotechnology Co. LTD, Guangzhou, China

Qi Tian

Affiliation The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China

Jun Zhang

Affiliation The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China

Rong-Liang Liang

Affiliation Institute of Antibody Engineering, School of Biotechnology, Southern Medical University, Guangzhou, China

Ming Li

Affiliation Institute of Antibody Engineering, School of Biotechnology, Southern Medical University, Guangzhou, China

Xue-Xi Yang

Contributed equally to this work with: Xue-Xi Yang, Ying-Song Wu

wg@smu.edu.cn (YSW); yxxzb@sohu.com (XXY)

Affiliation Institute of Antibody Engineering, School of Biotechnology, Southern Medical University, Guangzhou, China

Ying-Song Wu

Contributed equally to this work with: Xue-Xi Yang, Ying-Song Wu

wg@smu.edu.cn (YSW); yxxzb@sohu.com (XXY)

Affiliation Institute of Antibody Engineering, School of Biotechnology, Southern Medical University, Guangzhou, China

Competing Interests

Guangzhou Darui Biotechnology Co. LTD provided support in the form of salaries for two authors (Hai-Yan Gan and Fen-Xia Li) and its laboratories performed the part of the testing for clinical samples. There are no relevant products in development, or marketed products to declare. This does not alter our adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: XXY; YSW; XPX. Performed the experiments: XPX; FXL;RLL. Analyzed the data: XPX; HYG. Contributed reagents/materials/analysis tools: QT; JZ; ML; FXL; RLL;YSW. Wrote the paper: XPX; XXY.