About the Authors

Jennifer Krupka

Affiliation CSL Behring GmbH, Marburg, Germany

Frauke May

Affiliation CSL Behring GmbH, Marburg, Germany

Thomas Weimer

Affiliation CSL Behring GmbH, Marburg, Germany

Ingo Pragst

Affiliation CSL Behring GmbH, Marburg, Germany

Christoph Kleinschnitz

Affiliation University of Würzburg, Department of Neurology, Würzburg, Germany

Guido Stoll

Affiliation University of Würzburg, Department of Neurology, Würzburg, Germany

Con Panousis

Affiliation CSL Limited, Bio21 Institute, Parkville, Victoria, Australia

Gerhard Dickneite

Affiliation CSL Behring GmbH, Marburg, Germany

Marc W. Nolte

marc.nolte@cslbehring.com

Affiliation CSL Behring GmbH, Marburg, Germany

Competing Interests

JK, FM, TW, IP and MWN are employees of CSL Behring GmbH. GD has been an employee of CSL Behring GmbH. CP is an employee of CSL Limited. GS has been a consultant of CSL Behring GmbH. CK receives financial support from CSL Behring GmbH to conduct research on FXII in experimental stroke. Furthermore, CSL Behring holds a patent/ patent application regarding the FXIIa inhibitor rHA-Infestin-4 and the respective use (Name: Therapeutic application of Kazal-type serine protease inhibitors; Number: WO 2008/1098720 A1). The commercial affiliation of authors JK, FM, TW, IP, MWN, GD and CP as well as CSL Behring GmbH holding the patent do not alter our adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: MWN IP GD. Performed the experiments: JK MWN. Analyzed the data: JK MWN FM. Contributed reagents/materials/analysis tools: TW. Wrote the paper: JK MWN FM TW IP CK GS CP GD. Provided expert advice: CK GS CP.