About the Authors

Sini Kinnunen

Contributed equally to this work with: Sini Kinnunen, Mika Välimäki

Affiliations Division of Pharmacology and Pharmacotherapy, University of Helsinki, Helsinki, Finland, Institute of Biomedicine, Department of Pharmacology and Toxicology, University of Oulu, Oulu, Finland

Mika Välimäki

Contributed equally to this work with: Sini Kinnunen, Mika Välimäki

Affiliations Division of Pharmacology and Pharmacotherapy, University of Helsinki, Helsinki, Finland, Institute of Biomedicine, Department of Pharmacology and Toxicology, University of Oulu, Oulu, Finland

Marja Tölli

Affiliation Institute of Biomedicine, Department of Pharmacology and Toxicology, University of Oulu, Oulu, Finland

Gerd Wohlfahrt

Affiliation Orion Pharma, Computer-Aided Drug Design, Espoo, Finland

Rami Darwich

Affiliation Laboratory of Cardiac Development and Differentiation, Department of Biochemistry, Immunology and Microbiology, University of Ottawa, Ottawa, Canada

Hiba Komati

Affiliation Laboratory of Cardiac Development and Differentiation, Department of Biochemistry, Immunology and Microbiology, University of Ottawa, Ottawa, Canada

Mona Nemer

heikki.ruskoaho@helsinki.fi (HR); mona.nemer@uottawa.ca (MN)

Affiliation Laboratory of Cardiac Development and Differentiation, Department of Biochemistry, Immunology and Microbiology, University of Ottawa, Ottawa, Canada

Heikki Ruskoaho

heikki.ruskoaho@helsinki.fi (HR); mona.nemer@uottawa.ca (MN)

Affiliations Division of Pharmacology and Pharmacotherapy, University of Helsinki, Helsinki, Finland, Institute of Biomedicine, Department of Pharmacology and Toxicology, University of Oulu, Oulu, Finland

Competing Interests

Gerd Wohlfahrt is an employee of Orion Pharma, Espoo, Finland, but he has no competing interests with this study. This does not alter the authors’ adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: HR MN SK MT HK GW MV. Performed the experiments: SK MV RD HK. Analyzed the data: SK MV GW HK RD. Wrote the paper: SK MV MN HR.