Additive Renoprotection by Pioglitazone and Fenofibrate against Inflammatory, Oxidative and Apoptotic Manifestations of Cisplatin Nephrotoxicity: Modulation by PPARs

Mai M. Helmy; Maged W. Helmy; Mahmoud M. El-Mas

doi:10.1371/journal.pone.0142303

Loading metrics

Open Access

Peer-reviewed

Research Article

Additive Renoprotection by Pioglitazone and Fenofibrate against Inflammatory, Oxidative and Apoptotic Manifestations of Cisplatin Nephrotoxicity: Modulation by PPARs

Mai M. Helmy,

Affiliation Pharmacology and Toxicology, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt
⨯
Maged W. Helmy,

Affiliation Pharmacology and Toxicology, Faculty of Pharmacy, Damanhour University, Damanhour, Egypt
⨯
Mahmoud M. El-Mas

* E-mail: mahelm@hotmail.com

Affiliation Pharmacology and Toxicology, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt
⨯

Additive Renoprotection by Pioglitazone and Fenofibrate against Inflammatory, Oxidative and Apoptotic Manifestations of Cisplatin Nephrotoxicity: Modulation by PPARs

Mai M. Helmy,
Maged W. Helmy,
Mahmoud M. El-Mas

Published: November 4, 2015
https://doi.org/10.1371/journal.pone.0142303

About the Authors

Mai M. Helmy

Affiliation Pharmacology and Toxicology, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt

Maged W. Helmy

Affiliation Pharmacology and Toxicology, Faculty of Pharmacy, Damanhour University, Damanhour, Egypt

Mahmoud M. El-Mas

* E-mail: mahelm@hotmail.com

Affiliation Pharmacology and Toxicology, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MMH MWH MME. Performed the experiments: MMH MWH. Analyzed the data: MMH MWH MME. Contributed reagents/materials/analysis tools: MMH MWH. Wrote the paper: MMH MWH MME.

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Inflammation
Is the Subject Area "Inflammation" applicable to this article?

Thanks for your feedback.
Apoptosis
Is the Subject Area "Apoptosis" applicable to this article?

Thanks for your feedback.
Kidneys
Is the Subject Area "Kidneys" applicable to this article?

Thanks for your feedback.
Drug administration
Is the Subject Area "Drug administration" applicable to this article?

Thanks for your feedback.
Renal system
Is the Subject Area "Renal system" applicable to this article?

Thanks for your feedback.
Necrosis
Is the Subject Area "Necrosis" applicable to this article?

Thanks for your feedback.
Creatinine
Is the Subject Area "Creatinine" applicable to this article?

Thanks for your feedback.
Protein expression
Is the Subject Area "Protein expression" applicable to this article?

Thanks for your feedback.