About the Authors
- María Jose Rebollo-Lopez
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Affiliation Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, Madrid, Spain
- Joël Lelièvre
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* E-mail: joel.l.lelievre@gsk.com (JL); mmarti@pcb.ub.cat (MAMR)
Affiliation Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, Madrid, Spain
- Daniel Alvarez-Gomez
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Affiliation Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, Madrid, Spain
- Julia Castro-Pichel
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Affiliation Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, Madrid, Spain
- Francisco Martínez-Jiménez
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Affiliations Genome Biology Group, Centre Nacional d’Anàlisi Genòmica (CNAG), Barcelona, Spain, Gene Regulation Stem Cells and Cancer Program, Centre for Genomic Regulation (CRG), Barcelona, Spain
- George Papadatos
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Affiliation European Molecular Biology Laboratory–European Bioinformatics Institute (EMBL-EBI), Hinxton, Cambridge, United Kingdom
- Vinod Kumar
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Affiliation Computational Biology, Quantitative Sciences, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America
- Gonzalo Colmenarejo
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Affiliation Centro de Investigación Básica, CSci Computational Chemistry, GlaxoSmithKline, Tres Cantos, Madrid, Spain
- Grace Mugumbate
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Affiliation European Molecular Biology Laboratory–European Bioinformatics Institute (EMBL-EBI), Hinxton, Cambridge, United Kingdom
- Mark Hurle
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Affiliation Computational Biology, Quantitative Sciences, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America
- Vanessa Barroso
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Affiliation Centro de Investigación Básica, Platform Technology & Science, GlaxoSmithKline, Tres Cantos, Madrid, Spain
- Rob J. Young
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Affiliation CSC Medicinal Chemistry, Medicines Research Centre, GlaxoSmithKline, Stevenage, Hertfordshire, United Kingdom
- María Martinez-Hoyos
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Affiliation Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, Madrid, Spain
- Rubén González del Río
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Affiliation Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, Madrid, Spain
- Robert H. Bates
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Affiliation Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, Madrid, Spain
- Eva Maria Lopez-Roman
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Affiliation Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, Madrid, Spain
- Alfonso Mendoza-Losana
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Affiliation Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, Madrid, Spain
- James R. Brown
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Affiliation Computational Biology, Quantitative Sciences, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America
- Emilio Alvarez-Ruiz
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Affiliation Centro de Investigación Básica, Platform Technology & Science, GlaxoSmithKline, Tres Cantos, Madrid, Spain
- Marc A. Marti-Renom
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* E-mail: joel.l.lelievre@gsk.com (JL); mmarti@pcb.ub.cat (MAMR)
Affiliations Genome Biology Group, Centre Nacional d’Anàlisi Genòmica (CNAG), Barcelona, Spain, Gene Regulation Stem Cells and Cancer Program, Centre for Genomic Regulation (CRG), Barcelona, Spain, Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain
- John P. Overington
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Affiliation European Molecular Biology Laboratory–European Bioinformatics Institute (EMBL-EBI), Hinxton, Cambridge, United Kingdom
- Nicholas Cammack
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Affiliation Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, Madrid, Spain
- Lluís Ballell
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Affiliation Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, Madrid, Spain
- David Barros-Aguire
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Affiliation Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, Madrid, Spain
Competing Interests
The authors of this manuscript have the following competing interests: several authors are employed by GlaxoSmithKline. This does not alter their adherence to PLOS ONE policies on sharing data and materials.
Author Contributions
Conceived and designed the experiments: JRB JPO MAMR AM EAR. Performed the experiments: MJRL DAG FMJ GP VK VB EMLR GM MMH RGR. Analyzed the data: MJRL DAG FMJ GP MAMR VK MH JCP RHB GC RGR. Wrote the paper: JL MJRL FMJ GP JRB JPO MAMR GC AM RY EAR JCP LB DB RGR. Gave final approval: NC.