About the Authors

Maximilian Schmid

Affiliation Institute of Immunology, University of Regensburg, Regensburg, Germany

Bianca Dufner

Affiliation Institute of Immunology, University of Regensburg, Regensburg, Germany

Julius Dürk

Affiliation Institute of Immunology, University of Regensburg, Regensburg, Germany

Konstanze Bedal

Affiliation Institute of Immunology, University of Regensburg, Regensburg, Germany

Kristina Stricker

Affiliation Institute of Immunology, University of Regensburg, Regensburg, Germany

Lukas Ali Prokoph

Affiliation Institute of Immunology, University of Regensburg, Regensburg, Germany

Christoph Koch

Affiliation Institute of Immunology, University of Regensburg, Regensburg, Germany

Anja K. Wege

Affiliation Department of Gynecology and Obstetrics, University of Regensburg, Regensburg, Germany

Henner Zirpel

Affiliation Division of Immunology, Paul-Ehrlich-Institute, Langen, Germany

Ger van Zandbergen

Affiliations Department of Gynecology and Obstetrics, University of Regensburg, Regensburg, Germany, Institute of Immunology, University Medical Center of the Johannes Gutenberg University of Mainz, Mainz, Germany

Rupert Ecker

Affiliation TissueGnostics GmbH, Vienna, Austria

Bogdan Boghiu

Affiliation TissueGnostics GmbH, Vienna, Austria

Uwe Ritter

Uwe.Ritter@klinik.uni-regensburg.de

Affiliation Institute of Immunology, University of Regensburg, Regensburg, Germany

Competing Interests

Co-author Bogdan Boghiu is an employee of TissueGnostics GmbH (Vienna, Austria: [http://www.tissuegnostics.com]), a commercial company. Co-author Rupert Ecker is co-founder and Chief Executive Officer of TissueGnostics GmbH, as well as the co-inventor of the TissueFAXS Cytometry platform. The new algorithms described in the manuscript were developed together with TissueGnostics GmbH, and the company provided antibodies and reagents for this study. TissueGnostics GmbH sells Image- and Tissue-Cytometers including advanced image analysis software applications. There are no patents, commercial products in development or marketed products to declare. This does not alter the authors’ adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: MS UR. Performed the experiments: MS BD JD KB KS LAP CK HZ GVZ. Analyzed the data: MS RE BB UR. Contributed reagents/materials/analysis tools: MS UR RE. Wrote the paper: MS UR AKW.