About the Authors

Michael A. Ellison

Affiliation Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, United States of America

Gail Thurman

Affiliation Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, United States of America

Christy M. Gearheart

Affiliation Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, United States of America

Ryan H. Seewald

Affiliation Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, United States of America

Christopher C. Porter

Affiliation Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, United States of America

Daniel R. Ambruso

Daniel.ambruso@ucdenver.edu

Affiliations Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, United States of America, Department of Pediatrics, University of Colorado Denver, The Anschutz Medical Campus, Aurora, Colorado, United States of America, Department of Pathology, University of Colorado Denver, The Anschutz Medical Campus, Aurora, Colorado, United States of America, The Center for Cancer and Blood Disorders, Transfusion Services, Children's Hospital Colorado, Aurora, Colorado, United States of America, Hematology/Oncology and Bone Marrow Transplantation Laboratories, Aurora, Colorado, United States of America

Competing Interests

The authors have the following interests: This study was funded by Horizon Pharma Ireland Ltd. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: MAE GT CMG CCP DRA. Performed the experiments: MAE GT CMG RHS. Analyzed the data: MAE GT CMG. Contributed reagents/materials/analysis tools: MAE GT CMG. Wrote the paper: MAE GT CMG CCP DRA.