About the Authors

Jörg Täubel

j.taubel@sgul.ac.uk

Affiliations Richmond Pharmacology Ltd., St George's University of London, Cranmer Terrace, London, United Kingdom, Cardiovascular and Cell Sciences Research Institute, St George's University of London, Cranmer Terrace, London, United Kingdom

Georg Ferber

Affiliation Statistik Georg Ferber GmbH, Cagliostrostrasse, Riehen, Switzerland

Ulrike Lorch

Affiliation Richmond Pharmacology Ltd., St George's University of London, Cranmer Terrace, London, United Kingdom

Duolao Wang

Affiliation Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom

Mariano Sust

Affiliation Department of Clinical Investigation, ESTEVE Research & Development, Av. Mare de Déu de Montserrat, Barcelona, Spain

A. John Camm

Affiliation Cardiovascular and Cell Sciences Research Institute, St George's University of London, Cranmer Terrace, London, United Kingdom

Competing Interests

JT and UL are employees of Richmond Pharmacology Ltd., whose company provided funding towards this supplementary analysis. GF is an employee of Statistik Georg Ferber GmbH that received funding from Esteve and Richmond Pharmacology to carry out the statistical analysis of this study. MS is an employee of ESTEVE Research & Development, whose company provided funding towards the clinical trial and this supplementary analysis. There are no patents or marketed products todeclare from this supplementary analysis. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: JT UL MS. Performed the experiments: JT UL. Analyzed the data: GF DW AJC. Contributed reagents/materials/analysis tools: MS JT UL AJC GF DW. Wrote the paper: JT GF AJC.