About the Authors

Sarah Gooding

Affiliations Department of Haematology, Oxford University Hospitals NHS Trust, Churchill Hospital, Old Road, Headington, Oxford, OX3 7LE, United Kingdom, National Institute for Health Research (NIHR) Oxford Biomedical Research Centre, Oxford University Hospitals NHS Trust, Oxford, OX3 7LE, United Kingdom, MRC Human Immunology Unit, University of Oxford, Weatherall Institute of Molecular Medicine, Headley Way, Oxford, OX3 9DS, United Kingdom

I-Jun Lau

Affiliations Department of Haematology, Oxford University Hospitals NHS Trust, Churchill Hospital, Old Road, Headington, Oxford, OX3 7LE, United Kingdom, National Institute for Health Research (NIHR) Oxford Biomedical Research Centre, Oxford University Hospitals NHS Trust, Oxford, OX3 7LE, United Kingdom

Mimi Sheikh

Affiliations Department of Haematology, Oxford University Hospitals NHS Trust, Churchill Hospital, Old Road, Headington, Oxford, OX3 7LE, United Kingdom, National Institute for Health Research (NIHR) Oxford Biomedical Research Centre, Oxford University Hospitals NHS Trust, Oxford, OX3 7LE, United Kingdom, Department of Oncology, University of Oxford, Old Road Campus Research Building, Oxford University Old Road Campus, Oxford, OX3 7LH, United Kingdom

Pamela Roberts

Affiliation Department of Haematology, Oxford University Hospitals NHS Trust, Churchill Hospital, Old Road, Headington, Oxford, OX3 7LE, United Kingdom

Julia Wong

Affiliation Department of Haematology, Oxford University Hospitals NHS Trust, Churchill Hospital, Old Road, Headington, Oxford, OX3 7LE, United Kingdom

Emmy Dickens

Affiliations Department of Haematology, Oxford University Hospitals NHS Trust, Churchill Hospital, Old Road, Headington, Oxford, OX3 7LE, United Kingdom, National Institute for Health Research (NIHR) Oxford Biomedical Research Centre, Oxford University Hospitals NHS Trust, Oxford, OX3 7LE, United Kingdom

Ash Bullement

Affiliation BresMed Health Solutions, 84 Queen Street, North Church House, Sheffield, S1 2DW, United Kingdom

Jamie Elvidge

Affiliation BresMed Health Solutions, 84 Queen Street, North Church House, Sheffield, S1 2DW, United Kingdom

Dawn Lee

Affiliation BresMed Health Solutions, 84 Queen Street, North Church House, Sheffield, S1 2DW, United Kingdom

Karthik Ramasamy

karthik.ramasamy@ouh.nhs.uk

Affiliations Department of Haematology, Oxford University Hospitals NHS Trust, Churchill Hospital, Old Road, Headington, Oxford, OX3 7LE, United Kingdom, National Institute for Health Research (NIHR) Oxford Biomedical Research Centre, Oxford University Hospitals NHS Trust, Oxford, OX3 7LE, United Kingdom, Royal Berkshire Hospital NHS Trust, London Rd, Reading, RG1 5AN, United Kingdom

Competing Interests

AB, JE and DL are employees of BresMed, which receives consultancy fees from Celgene. SG, IL, MS, PR, JW, ED, KR are members of a hospital department that has received an unrestricted educational grant from Celgene. KR is in receipt of honoraria from Celgene. No author has any direct financial interests whose value could be affected by this publication. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: SG KR. Performed the experiments: SG IL MS ED KR. Analyzed the data: SG AB JE DL KR. Contributed reagents/materials/analysis tools: PR JW. Wrote the paper: SG DL KR.