About the Authors

Yukihiko Hiroshima

Affiliations AntiCancer, Inc., San Diego, California, United States of America, Department of Surgery, University of California San Diego, San Diego, California, United States of America, Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan

Ming Zhao

Affiliation AntiCancer, Inc., San Diego, California, United States of America

Yong Zhang

Affiliation AntiCancer, Inc., San Diego, California, United States of America

Nan Zhang

Affiliation AntiCancer, Inc., San Diego, California, United States of America

Ali Maawy

Affiliation Department of Surgery, University of California San Diego, San Diego, California, United States of America

Takashi Murakami

Affiliations AntiCancer, Inc., San Diego, California, United States of America, Department of Surgery, University of California San Diego, San Diego, California, United States of America, Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan

Sumiyuki Mii

Affiliations AntiCancer, Inc., San Diego, California, United States of America, Department of Surgery, University of California San Diego, San Diego, California, United States of America

Fuminari Uehara

Affiliations AntiCancer, Inc., San Diego, California, United States of America, Department of Surgery, University of California San Diego, San Diego, California, United States of America

Mako Yamamoto

Affiliations AntiCancer, Inc., San Diego, California, United States of America, Department of Surgery, University of California San Diego, San Diego, California, United States of America

Shinji Miwa

Affiliations AntiCancer, Inc., San Diego, California, United States of America, Department of Surgery, University of California San Diego, San Diego, California, United States of America

Shuya Yano

Affiliations AntiCancer, Inc., San Diego, California, United States of America, Department of Surgery, University of California San Diego, San Diego, California, United States of America

Masashi Momiyama

Affiliation Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan

Ryutaro Mori

Affiliation Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan

Ryusei Matsuyama

Affiliation Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan

Takashi Chishima

Affiliation Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan

Kuniya Tanaka

Affiliation Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan

Yasushi Ichikawa

Affiliation Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan

Michael Bouvet

Affiliation Department of Surgery, University of California San Diego, San Diego, California, United States of America

Itaru Endo

Affiliation Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan

Robert M. Hoffman

all@anticancer.com

Affiliations AntiCancer, Inc., San Diego, California, United States of America, Department of Surgery, University of California San Diego, San Diego, California, United States of America

Competing Interests

Ming Zhao, Yong Zhang and Nan Zhang are employees of AntiCancer Inc. Yukihiko Hiroshima, Takashi Murakami, Mako Yamamoto, Shinji Miwa, Shuya Yano, and Robert M. Hoffman are unpaid affiliates of AntiCancer Inc. Sumiyuki Mii, Fuminari Uehara, Masashi Momiyama and Takashi Chishima were former affiliates of AntiCancer Inc. AntiCancer Inc. markets animal models of cancer. There are no other competing interests. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: YH RMH. Performed the experiments: YH MZ YZ NZ AM. Analyzed the data: YH MZ YZ NZ AM TM SuM FU MY ShM SY MM RMo RMa TC KT YI MB IE RMH. Contributed reagents/materials/analysis tools: RMH. Wrote the paper: YH RMH.