About the Authors

Bo-Juen Chen

Affiliations Department of Biomedical Informatics, Columbia University, New York, New York, 10032, United States of America, Department of Biological Sciences, Department of Systems Biology, Columbia University, New York, New York, 10027, United States of America

Oren Litvin

Affiliation Department of Biological Sciences, Department of Systems Biology, Columbia University, New York, New York, 10027, United States of America

Lyle Ungar

Affiliation Computer and Information Science, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, United States of America

Dana Pe’er

dpeer@biology.columbia.edu

Affiliation Department of Biological Sciences, Department of Systems Biology, Columbia University, New York, New York, 10027, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: BJC LU DP. Analyzed the data: BJC OL LU DP. Wrote the paper: BJC LU DP. Developed the CHER algorithm: BJC LU DP. Implemented the CHER algorithm: BJC.