About the Authors

Lena Hafrén

Contributed equally to this work with: Lena Hafrén, Elisabet Einarsdottir

lena.hafren@helsinki.fi (LH); petri.mattila@helsinki.fi (PSM)

Affiliation Department of Otorhinolaryngology, Helsinki University Central Hospital, Helsinki, Finland

Elisabet Einarsdottir

Contributed equally to this work with: Lena Hafrén, Elisabet Einarsdottir

Affiliation Department of Biosciences and Nutrition, Center for Innovative Medicine, Karolinska Institutet, Huddinge, Sweden

Erna Kentala

Affiliation Department of Otorhinolaryngology, Helsinki University Central Hospital, Helsinki, Finland

Sari Hammarén-Malmi

Affiliation Department of Otorhinolaryngology, Helsinki University Central Hospital, Helsinki, Finland

Mahmood F. Bhutta

Affiliation UCL Ear Institute, London, United Kingdom

Carol J. MacArthur

Affiliation Department of Otolaryngology, Head & Neck Surgery, Oregon Health & Science University, Portland, Oregon, United States of America

Beth Wilmot

Affiliation Oregon Clinical and Translational Research Institute and Division of Bioinformatics and Computational Biology, Oregon Health & Science University, Portland, Oregon, United States of America

Margaretha Casselbrant

Affiliation Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

Yvette P. Conley

Affiliation Department of Nursing and Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Daniel E. Weeks

Affiliation Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Ellen M. Mandel

Affiliation Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

Outi Vaarala

Affiliation Institute of Clinical Medicine, University of Helsinki, Helsinki, Finland

Anna Kallio

Affiliation Department of Vaccination and Immune Protection, National Institute for Health and Welfare (THL), Helsinki, Finland

Merit Melin

Affiliation Department of Vaccination and Immune Protection, National Institute for Health and Welfare (THL), Helsinki, Finland

Janne K. Nieminen

Affiliation Department of Vaccination and Immune Protection, National Institute for Health and Welfare (THL), Helsinki, Finland

Eira Leinonen

Affiliation Molecular Neurology Research Program, University of Helsinki and Folkhälsan Institute of Genetics, Helsinki, Finland

Juha Kere

Affiliations Department of Biosciences and Nutrition, Center for Innovative Medicine, Karolinska Institutet, Huddinge, Sweden, Molecular Neurology Research Program, University of Helsinki and Folkhälsan Institute of Genetics, Helsinki, Finland

Petri S. Mattila

lena.hafren@helsinki.fi (LH); petri.mattila@helsinki.fi (PSM)

Affiliation Department of Otorhinolaryngology, Helsinki University Central Hospital, Helsinki, Finland

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LH EE AK MM OV JKN JK PSM. Performed the experiments: LH EE MFB CJM BW YPC EMM AK JKN EL. Analyzed the data: LH EE MFB CJM BW YPC DEW EMM OV AK MM JKN PSM. Contributed reagents/materials/analysis tools: LH EE EK SHM MFB CJM BW MC YPC DEW EMM OV AK MM JKN EL JK PSM. Wrote the paper: LH EE EK MFB MC DEW OV AK MM JKN EL JK PSM.