About the Authors

Magdalena Dorywalska

Contributed equally to this work with: Magdalena Dorywalska, Pavel Strop

Affiliation Rinat Laboratories, Pfizer Inc., 230 East Grand Avenue, South San Francisco, CA, 94080, United States of America

Pavel Strop

Contributed equally to this work with: Magdalena Dorywalska, Pavel Strop

pavel.strop@pfizer.com

Affiliation Rinat Laboratories, Pfizer Inc., 230 East Grand Avenue, South San Francisco, CA, 94080, United States of America

Jody A. Melton-Witt

Affiliation Rinat Laboratories, Pfizer Inc., 230 East Grand Avenue, South San Francisco, CA, 94080, United States of America

Adela Hasa-Moreno

Affiliation Rinat Laboratories, Pfizer Inc., 230 East Grand Avenue, South San Francisco, CA, 94080, United States of America

Santiago E. Farias

Affiliation Rinat Laboratories, Pfizer Inc., 230 East Grand Avenue, South San Francisco, CA, 94080, United States of America

Meritxell Galindo Casas

Affiliation Rinat Laboratories, Pfizer Inc., 230 East Grand Avenue, South San Francisco, CA, 94080, United States of America

Kathy Delaria

Affiliation Rinat Laboratories, Pfizer Inc., 230 East Grand Avenue, South San Francisco, CA, 94080, United States of America

Victor Lui

Affiliation Rinat Laboratories, Pfizer Inc., 230 East Grand Avenue, South San Francisco, CA, 94080, United States of America

Kris Poulsen

Affiliation Rinat Laboratories, Pfizer Inc., 230 East Grand Avenue, South San Francisco, CA, 94080, United States of America

Janette Sutton

Affiliation Rinat Laboratories, Pfizer Inc., 230 East Grand Avenue, South San Francisco, CA, 94080, United States of America

Gary Bolton

Affiliation Rinat Laboratories, Pfizer Inc., 230 East Grand Avenue, South San Francisco, CA, 94080, United States of America

Dahui Zhou

Affiliation Worldwide Medicinal Chemistry, Pfizer Inc., 445 Eastern Point Road, Groton, CT, 06340, United States of America

Ludivine Moine

Affiliation Worldwide Medicinal Chemistry, Pfizer Inc., 445 Eastern Point Road, Groton, CT, 06340, United States of America

Russell Dushin

Affiliation Worldwide Medicinal Chemistry, Pfizer Inc., 445 Eastern Point Road, Groton, CT, 06340, United States of America

Thomas-Toan Tran

Affiliation Rinat Laboratories, Pfizer Inc., 230 East Grand Avenue, South San Francisco, CA, 94080, United States of America

Shu-Hui Liu

Affiliation Rinat Laboratories, Pfizer Inc., 230 East Grand Avenue, South San Francisco, CA, 94080, United States of America

Mathias Rickert

Affiliation Rinat Laboratories, Pfizer Inc., 230 East Grand Avenue, South San Francisco, CA, 94080, United States of America

Davide Foletti

Affiliation Rinat Laboratories, Pfizer Inc., 230 East Grand Avenue, South San Francisco, CA, 94080, United States of America

David L. Shelton

Affiliation Rinat Laboratories, Pfizer Inc., 230 East Grand Avenue, South San Francisco, CA, 94080, United States of America

Jaume Pons

Affiliation Rinat Laboratories, Pfizer Inc., 230 East Grand Avenue, South San Francisco, CA, 94080, United States of America

Arvind Rajpal

Affiliation Rinat Laboratories, Pfizer Inc., 230 East Grand Avenue, South San Francisco, CA, 94080, United States of America

Competing Interests

All authors are employees of Pfizer Inc. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: MD PS S-HL DF DLS AR. Performed the experiments: MD JAM-W AH-M SEF VL JS GB T-TT. Analyzed the data: MD PS JAM-W AH-M SEF VL DF. Contributed reagents/materials/analysis tools: MD JAM-W AH-M SEF MGC KD KP DZ LM MR. Wrote the manuscript: MD PS. Critically reviewed the manuscript: SEF RD DF DLS JP AR.