Overexpression of the Large-Conductance, Ca2+-Activated K+ (BK) Channel Shortens Action Potential Duration in HL-1 Cardiomyocytes

Joseph R. Stimers; Li Song; Nancy J. Rusch; Sung W. Rhee

doi:10.1371/journal.pone.0130588

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Open Access

Peer-reviewed

Research Article

Overexpression of the Large-Conductance, Ca²⁺-Activated K⁺ (BK) Channel Shortens Action Potential Duration in HL-1 Cardiomyocytes

Joseph R. Stimers ,

* E-mail: StimersJosephR@uams.edu

Affiliation Department of Pharmacology & Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America
⨯
Li Song,

Affiliation Department of Pharmacology & Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America
⨯
Nancy J. Rusch,

Affiliation Department of Pharmacology & Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America
⨯
Sung W. Rhee

Affiliation Department of Pharmacology & Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America
⨯

Overexpression of the Large-Conductance, Ca²⁺-Activated K⁺ (BK) Channel Shortens Action Potential Duration in HL-1 Cardiomyocytes

Joseph R. Stimers,
Li Song,
Nancy J. Rusch,
Sung W. Rhee

Published: June 19, 2015
https://doi.org/10.1371/journal.pone.0130588

About the Authors

Joseph R. Stimers

* E-mail: StimersJosephR@uams.edu

Affiliation Department of Pharmacology & Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America

Li Song

Affiliation Department of Pharmacology & Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America

Nancy J. Rusch

Affiliation Department of Pharmacology & Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America

Sung W. Rhee

Affiliation Department of Pharmacology & Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JRS LS NJR SWR. Performed the experiments: JRS LS. Analyzed the data: JRS LS SWR. Contributed reagents/materials/analysis tools: JRS LS NJR SWR. Wrote the paper: JRS LS NJR SWR.

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Calcium-activated potassium channels
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Transfection
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Potassium channels
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Muscle cells
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Ion channels
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K cells
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Action potentials
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Membrane potential
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