About the Authors

Emily J. Shields

Affiliation McNair Medical Institute, Pediatric Diabetes and Endocrinology, Baylor College of Medicine, Texas Children’s Hospital, Houston, TX, United States of America

Carol J. Lam

Affiliation McNair Medical Institute, Pediatric Diabetes and Endocrinology, Baylor College of Medicine, Texas Children’s Hospital, Houston, TX, United States of America

Aaron R. Cox

Affiliation McNair Medical Institute, Pediatric Diabetes and Endocrinology, Baylor College of Medicine, Texas Children’s Hospital, Houston, TX, United States of America

Matthew M. Rankin

Affiliation Pediatric Endocrinology and Diabetes, Children’s Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America

Thomas J. Van Winkle

Affiliation Matthew J. Ryan Veterinary Hospital, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, United States of America

Rebecka S. Hess

Affiliation Matthew J. Ryan Veterinary Hospital, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, United States of America

Jake A. Kushner

kushner@bcm.edu

Affiliation McNair Medical Institute, Pediatric Diabetes and Endocrinology, Baylor College of Medicine, Texas Children’s Hospital, Houston, TX, United States of America

Competing Interests

JAK has served on the scientific advisory board of Johnson & Johnson and currently serves on an advisory board for Lexicon. No other potential conflicts of interest relevant to this article were reported. As requested, the authors reply that this does not alter their adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: EJS RSH JAK. Performed the experiments: EJS CJL ARC MMR TJVW RSH JAK. Analyzed the data: EJS RSH JAK. Wrote the paper: EJS RSH JAK.