About the Authors

Shinichi Matsuda

matsudasni@chugai-pharm.co.jp

Affiliation Drug Safety Division, Chugai Pharmaceutical Co. Ltd., Tokyo, Japan

Kotonari Aoki

Affiliation Drug Safety Division, Chugai Pharmaceutical Co. Ltd., Tokyo, Japan

Takuya Kawamata

Affiliation Drug Safety Division, Chugai Pharmaceutical Co. Ltd., Tokyo, Japan

Tetsuji Kimotsuki

Affiliation Drug Safety Division, Chugai Pharmaceutical Co. Ltd., Tokyo, Japan

Takumi Kobayashi

Affiliation Drug Safety Division, Chugai Pharmaceutical Co. Ltd., Tokyo, Japan

Hiroshi Kuriki

Affiliation Clinical Development Division, Chugai Pharmaceutical Co. Ltd., Tokyo, Japan

Terumi Nakayama

Affiliation Drug Safety Division, Chugai Pharmaceutical Co. Ltd., Tokyo, Japan

Seigo Okugawa

Affiliation Drug Safety Division, Chugai Pharmaceutical Co. Ltd., Tokyo, Japan

Yoshihiko Sugimura

Affiliation Drug Safety Division, Chugai Pharmaceutical Co. Ltd., Tokyo, Japan

Minami Tomita

Affiliation Drug Safety Division, Chugai Pharmaceutical Co. Ltd., Tokyo, Japan

Yoichiro Takahashi

Affiliation Drug Safety Division, Chugai Pharmaceutical Co. Ltd., Tokyo, Japan

Competing Interests

All authors are employees of Chugai Pharmaceutical Co. Ltd. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: SM KA T. Kawamata T. Kobayashi T. Kimotsuki HK TN SO YS YT. Performed the experiments: SM T. Kawamata SO YS TN MT. Analyzed the data: SM HK. Wrote the paper: SM. Significant critical input: SM KA YT.