Dietary Vitamin D3 Restriction Exacerbates Disease Pathophysiology in the Spinal Cord of the G93A Mouse Model of Amyotrophic Lateral Sclerosis

Elnaz Moghimi; Jesse A. Solomon; Alexandro Gianforcaro; Mazen J. Hamadeh

doi:10.1371/journal.pone.0126355

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Open Access

Peer-reviewed

Research Article

Dietary Vitamin D₃ Restriction Exacerbates Disease Pathophysiology in the Spinal Cord of the G93A Mouse Model of Amyotrophic Lateral Sclerosis

Elnaz Moghimi,

Affiliations School of Kinesiology and Health Science, Faculty of Health, York University, Toronto, Ontario, Canada, Muscle Health Research Centre, York University, Toronto, Ontario, Canada
⨯
Jesse A. Solomon,

Affiliations School of Kinesiology and Health Science, Faculty of Health, York University, Toronto, Ontario, Canada, Muscle Health Research Centre, York University, Toronto, Ontario, Canada
⨯
Alexandro Gianforcaro,

Affiliations School of Kinesiology and Health Science, Faculty of Health, York University, Toronto, Ontario, Canada, Muscle Health Research Centre, York University, Toronto, Ontario, Canada
⨯
Mazen J. Hamadeh

* E-mail: hamadeh@yorku.ca

Affiliations School of Kinesiology and Health Science, Faculty of Health, York University, Toronto, Ontario, Canada, Muscle Health Research Centre, York University, Toronto, Ontario, Canada
⨯

Dietary Vitamin D₃ Restriction Exacerbates Disease Pathophysiology in the Spinal Cord of the G93A Mouse Model of Amyotrophic Lateral Sclerosis

Elnaz Moghimi,
Jesse A. Solomon,
Alexandro Gianforcaro,
Mazen J. Hamadeh

Published: May 28, 2015
https://doi.org/10.1371/journal.pone.0126355

About the Authors

Elnaz Moghimi

Affiliations School of Kinesiology and Health Science, Faculty of Health, York University, Toronto, Ontario, Canada, Muscle Health Research Centre, York University, Toronto, Ontario, Canada

Jesse A. Solomon

Affiliations School of Kinesiology and Health Science, Faculty of Health, York University, Toronto, Ontario, Canada, Muscle Health Research Centre, York University, Toronto, Ontario, Canada

Alexandro Gianforcaro

Affiliations School of Kinesiology and Health Science, Faculty of Health, York University, Toronto, Ontario, Canada, Muscle Health Research Centre, York University, Toronto, Ontario, Canada

Mazen J. Hamadeh

* E-mail: hamadeh@yorku.ca

Affiliations School of Kinesiology and Health Science, Faculty of Health, York University, Toronto, Ontario, Canada, Muscle Health Research Centre, York University, Toronto, Ontario, Canada

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MJH JAS AG. Performed the experiments: EM MJH. Analyzed the data: EM. Contributed reagents/materials/analysis tools: MJH. Wrote the paper: EM MJH.

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Diet
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Spinal cord
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Vitamins
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Body weight
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Vitamin D
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Mouse models
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Vitamin D deficiency
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Estrogens
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