About the Authors

Yifan Zhang

Contributed equally to this work with: Yifan Zhang, Angéla Kecskés

Affiliation Laboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, University of Leuven, Leuven, Belgium

Angéla Kecskés

Contributed equally to this work with: Yifan Zhang, Angéla Kecskés

Affiliation Laboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, University of Leuven, Leuven, Belgium

Daniëlle Copmans

‡ These authors also contributed equally to this work.

Affiliation Laboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, University of Leuven, Leuven, Belgium

Mélanie Langlois

‡ These authors also contributed equally to this work.

Affiliation Luxembourg Center for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg

Alexander D. Crawford

Affiliations Laboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, University of Leuven, Leuven, Belgium, Luxembourg Center for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg

Berten Ceulemans

Affiliation Department of Neurology-Child Neurology, University Hospital Antwerp & University of Antwerp, Antwerp, Belgium

Lieven Lagae

Affiliation Department of Paediatric Neurology, University Hospitals Leuven, Leuven, Belgium

Peter A. M. de Witte

peter.dewitte@pharm.kuleuven.be

Affiliation Laboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, University of Leuven, Leuven, Belgium

Camila V. Esguerra

Current address: Chemical Neuroscience Group, Biotechnology Centre of Oslo, University of Oslo, Oslo, Norway

Affiliation Laboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, University of Leuven, Leuven, Belgium

Competing Interests

Drs. Ceulemans and Lagae receive consultancy honoraria from Brabant Pharma. This does not alter the authors' adherence to all PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: AK ADC BC LL PAMW CVE. Performed the experiments: YZ AK DC. Analyzed the data: YZ AK DC ML PAMW CVE. Contributed reagents/materials/analysis tools: BC. Wrote the paper: YZ AK DC ML ADC BC LL PAMW CVE.