About the Authors
- Sethu Sankaranarayanan
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* E-mail: sethus2008@gmail.com (SS); kbrunden@upenn.edu (KB); Michael.Ahlijanian@bms.com (MA)
Affiliation Research and Development, Bristol-Myers Squibb, Wallingford, Connecticut, United States of America
- Donna M. Barten
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Affiliation Research and Development, Bristol-Myers Squibb, Wallingford, Connecticut, United States of America
- Laurel Vana
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Affiliation Center for Neurodegenerative Disease Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
- Nino Devidze
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Affiliation Research and Development, Bristol-Myers Squibb, Wallingford, Connecticut, United States of America
- Ling Yang
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Affiliation Research and Development, Bristol-Myers Squibb, Wallingford, Connecticut, United States of America
- Gregory Cadelina
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Affiliation Research and Development, Bristol-Myers Squibb, Wallingford, Connecticut, United States of America
- Nina Hoque
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Affiliation Research and Development, Bristol-Myers Squibb, Wallingford, Connecticut, United States of America
- Lynn DeCarr
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Affiliation Research and Development, Bristol-Myers Squibb, Wallingford, Connecticut, United States of America
- Stefanie Keenan
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Affiliation Research and Development, Bristol-Myers Squibb, Wallingford, Connecticut, United States of America
- Alan Lin
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Affiliation Research and Development, Bristol-Myers Squibb, Wallingford, Connecticut, United States of America
- Yang Cao
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Affiliation Research and Development, Bristol-Myers Squibb, Wallingford, Connecticut, United States of America
- Bradley Snyder
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Affiliation Research and Development, Bristol-Myers Squibb, Wallingford, Connecticut, United States of America
- Bin Zhang
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Affiliation Center for Neurodegenerative Disease Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
- Magdalena Nitla
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Affiliation Center for Neurodegenerative Disease Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
- Gregg Hirschfeld
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Affiliation Research and Development, Bristol-Myers Squibb, Wallingford, Connecticut, United States of America
- Nestor Barrezueta
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Affiliation Research and Development, Bristol-Myers Squibb, Wallingford, Connecticut, United States of America
- Craig Polson
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Affiliation Research and Development, Bristol-Myers Squibb, Wallingford, Connecticut, United States of America
- Paul Wes
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Affiliation Research and Development, Bristol-Myers Squibb, Wallingford, Connecticut, United States of America
- Vangipuram S. Rangan
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Affiliation Research and Development, Bristol-Myers Squibb, Redwood City, California, United States of America
- Angela Cacace
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Affiliation Research and Development, Bristol-Myers Squibb, Wallingford, Connecticut, United States of America
- Charles F. Albright
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Affiliation Research and Development, Bristol-Myers Squibb, Wallingford, Connecticut, United States of America
- Jere Meredith Jr.
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Affiliation Research and Development, Bristol-Myers Squibb, Wallingford, Connecticut, United States of America
- John Q. Trojanowski
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Affiliation Center for Neurodegenerative Disease Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
- Virginia M-Y. Lee
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Affiliation Center for Neurodegenerative Disease Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
- Kurt R. Brunden
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* E-mail: sethus2008@gmail.com (SS); kbrunden@upenn.edu (KB); Michael.Ahlijanian@bms.com (MA)
Affiliation Center for Neurodegenerative Disease Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
- Michael Ahlijanian
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* E-mail: sethus2008@gmail.com (SS); kbrunden@upenn.edu (KB); Michael.Ahlijanian@bms.com (MA)
Affiliation Research and Development, Bristol-Myers Squibb, Wallingford, Connecticut, United States of America
Competing Interests
I have read the journal's policy and the authors of this manuscript have the following competing interests: SS, DB, ND, LY, GC, NH, LD, SK, AL, YC, BS, GH, NB, CP, PW, VR, AC, CA, JM, MA are/were employees of Bristol-Myers Squibb, whose company partly funded this study. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.
Author Contributions
Conceived and designed the experiments: SS DB LV ND PW AC CA JMJ JT VL KB MA. Performed the experiments: SS LV ND LY GC NH LD SK AL YC BS BZ MN GH NB CP. Analyzed the data: SS DB LV ND LY NH LD SK AL YC BS BZ MN CP PW JMJ KB. Contributed reagents/materials/analysis tools: LY BZ MN CP VR. Wrote the paper: SS DB LV ND LY GC NH LD AL YC BZ MN JMJ JT VL KB MA.