About the Authors

Jiyang Jiang

Affiliation Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales, Randwick NSW, Australia

Wei Wen

w.wen@unsw.edu.au

Affiliations Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales, Randwick NSW, Australia, Neuropsychiatric Institute, Prince of Wales Hospital, Randwick NSW, Australia

David A. Brown

Affiliation Centre for Applied Medical Research, St. Vincent’s Hospital and University of New South Wales, Darlinghurst NSW, Australia

John Crawford

Affiliation Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales, Randwick NSW, Australia

Anbupalam Thalamuthu

Affiliation Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales, Randwick NSW, Australia

Evelyn Smith

Affiliation Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales, Randwick NSW, Australia

Samuel N. Breit

Affiliation Centre for Applied Medical Research, St. Vincent’s Hospital and University of New South Wales, Darlinghurst NSW, Australia

Tao Liu

Affiliation School of Biological Science and Medical Engineering, Beihang University, Beijing, China

Wanlin Zhu

Affiliation State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China

Henry Brodaty

Affiliations Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales, Randwick NSW, Australia, Aged Care Psychiatry, Prince of Wales Hospital, Randwick NSW, Australia, Dementia Collaborative Research Centre, University of New South Wales, Sydney NSW, Australia

Bernhard T. Baune

Affiliation Discipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, SA, Australia

Julian N. Trollor

Affiliations Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales, Randwick NSW, Australia, Department of Development Disability Neuropsychiatry, School of Psychiatry, University of New South Wales, Sydney NSW, Australia

Perminder S. Sachdev

Affiliations Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales, Randwick NSW, Australia, Neuropsychiatric Institute, Prince of Wales Hospital, Randwick NSW, Australia

Competing Interests

The authors confirm that David A. Brown is one of the members in the PLOS ONE Editorial Board. The authors have read the journal’s policy and have the following conflicts: DAB and SNB are named inventors on patents owned by St Vincent’s Hospital that pertain to the clinical use of a MIC-1/GDF15 diagnostic assay and modulatory therapy. St Vincent’s Hospital agrees to make freely available any materials and information described in this publication that may be reasonably requested for the purpose of academic, non-commercial research. Due to the proprietary nature of the materials, the parties will need to enter into a material transfer agreement. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: JJ WW DAB ES SNB HB BTB JNT PSS. Performed the experiments: JJ WW PSS JNT DAB SNB. Analyzed the data: JJ JC AT WZ TL. Contributed reagents/materials/analysis tools: JC AT WZ TL. Wrote the paper: JJ WW.