About the Authors

Kensuke Sakuma

kensuke.sakuma@takeda.com (KS)

‡ These authors contributed equally to this work.

Affiliation Cardiovascular and Metabolic Drug Discovery Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan

Hidetoshi Komatsu

‡ These authors contributed equally to this work.

Affiliation Central Nervous System Drug Discovery Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan

Minoru Maruyama

Affiliation Cardiovascular and Metabolic Drug Discovery Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan

Sachiko Imaichi

Affiliation Integrated Technology Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan

Yugo Habata

Affiliation Cardiovascular and Metabolic Drug Discovery Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan

Masaaki Mori

Affiliation Cardiovascular and Metabolic Drug Discovery Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan

Competing Interests

All authors are employees of Takeda Pharmaceutical Company Limit. All materials and compounds used in this study are commercially available. There are no patents and products in development or market products to declare. This does not alter the authors’ adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: KS HK. Performed the experiments: KS HK M. Maruyama SI. Analyzed the data: KS HK. Wrote the paper: KS HK M. Maruyama SI YH M. Mori. Supervised the project and contributed to experimental design: YH M. Mori.