About the Authors
- Sonya Barnes
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Affiliation The Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America
- You-Hai Xu
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Affiliations The Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America, The Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
- Wujuan Zhang
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Affiliation The Division of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America
- Benjamin Liou
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Affiliation The Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America
- Kenneth D. R. Setchell
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Affiliations The Division of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America, The Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
- Liming Bao
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Affiliation Dartmouth-Hitchcock Medical Center, Geisel School of Medicine, Dartmouth College, Lebanon, New Hampshire, United States of America
- Gregory A. Grabowski
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Affiliations The Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America, Synageva BioPharma Corp., Lexington, Massachusetts, United States of America
- Ying Sun
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* E-mail: ying.sun@cchmc.org
Affiliations The Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America, The Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
Competing Interests
The authors have the following interests: GAG is employed as the Chief Scientific Officer of Synageva BioPharma Corp. and has stock options in the company. Synageva Biopharma Corp. does not have projects relevant to this research topic nor vested interest in this work. Also, all the experiments were conducted at CCHMC, while GAG was employed there and were conducted under the auspices of a NIH grant (DK 36729) to GAG. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.
Author Contributions
Conceived and designed the experiments: YHX GAG YS. Performed the experiments: SB WZ BL YHX YS. Analyzed the data: SB YHX WZ GAG YS KDRS LB. Wrote the paper: SB YHX GAG YS.