About the Authors

Zachary B. Smithline

Contributed equally to this work with: Zachary B. Smithline, Anna S. Nikonova

Affiliations Yale University, New Haven, Connecticut, 06520, United States of America, Program in Molecular Therapeutics, Fox Chase Cancer Center, Philadelphia, Pennsylvania, 19111, United States of America

Anna S. Nikonova

Contributed equally to this work with: Zachary B. Smithline, Anna S. Nikonova

Affiliation Program in Molecular Therapeutics, Fox Chase Cancer Center, Philadelphia, Pennsylvania, 19111, United States of America

Harvey H. Hensley

Affiliation Program in Molecular Therapeutics, Fox Chase Cancer Center, Philadelphia, Pennsylvania, 19111, United States of America

Kathy Q. Cai

Affiliation Program in Molecular Therapeutics, Fox Chase Cancer Center, Philadelphia, Pennsylvania, 19111, United States of America

Brian L. Egleston

Affiliation Program in Molecular Therapeutics, Fox Chase Cancer Center, Philadelphia, Pennsylvania, 19111, United States of America

David A. Proia

Affiliation Synta Pharmaceuticals, Lexington, Massachusetts, 02421, United States of America

Tamina Seeger-Nukpezah

Erica.Golemis@fccc.edu (EAG); tamina.seeger-nukpezah@uk-koeln.de (TSN)

Affiliations Program in Molecular Therapeutics, Fox Chase Cancer Center, Philadelphia, Pennsylvania, 19111, United States of America, Department I of Internal Medicine, Center for Integrated Oncology, University Hospital of Cologne, Cologne, 50937, Germany

Erica A. Golemis

Erica.Golemis@fccc.edu (EAG); tamina.seeger-nukpezah@uk-koeln.de (TSN)

Affiliation Program in Molecular Therapeutics, Fox Chase Cancer Center, Philadelphia, Pennsylvania, 19111, United States of America

Competing Interests

D. P., is employed by a commercial company, Synta Pharmaceuticals. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: ZBS ASN TSN DAP EAG. Performed the experiments: ZBS ASN TSN KQC. Analyzed the data: ZBS ASN TSN HHH KQC BLE. Contributed reagents/materials/analysis tools: HHH KQC BLE. Wrote the paper: ZBC EAG TSN ASN DAP.