In COS Cells Vpu Can Both Stabilize Tetherin Expression and Counteract Its Antiviral Activity

Abdul A. Waheed; Nishani D. Kuruppu; Kathryn L. Felton; Darren D’Souza; Eric O. Freed

doi:10.1371/journal.pone.0111628

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Peer-reviewed

Research Article

In COS Cells Vpu Can Both Stabilize Tetherin Expression and Counteract Its Antiviral Activity

Abdul A. Waheed ,

* E-mail: waheedab@mail.nih.gov

Affiliation Virus-Cell Interaction Section, HIV Drug Resistance Program, NCI-Frederick, Frederick, Maryland, United States of America
⨯
Nishani D. Kuruppu,

Affiliation Virus-Cell Interaction Section, HIV Drug Resistance Program, NCI-Frederick, Frederick, Maryland, United States of America
⨯
Kathryn L. Felton,

Affiliation Virus-Cell Interaction Section, HIV Drug Resistance Program, NCI-Frederick, Frederick, Maryland, United States of America
⨯
Darren D’Souza,

Affiliation Virus-Cell Interaction Section, HIV Drug Resistance Program, NCI-Frederick, Frederick, Maryland, United States of America
⨯
Eric O. Freed

Affiliation Virus-Cell Interaction Section, HIV Drug Resistance Program, NCI-Frederick, Frederick, Maryland, United States of America
⨯

In COS Cells Vpu Can Both Stabilize Tetherin Expression and Counteract Its Antiviral Activity

Abdul A. Waheed,
Nishani D. Kuruppu,
Kathryn L. Felton,
Darren D’Souza,
Eric O. Freed

Published: October 31, 2014
https://doi.org/10.1371/journal.pone.0111628

About the Authors

Abdul A. Waheed

* E-mail: waheedab@mail.nih.gov

Affiliation Virus-Cell Interaction Section, HIV Drug Resistance Program, NCI-Frederick, Frederick, Maryland, United States of America

Nishani D. Kuruppu

Affiliation Virus-Cell Interaction Section, HIV Drug Resistance Program, NCI-Frederick, Frederick, Maryland, United States of America

Kathryn L. Felton

Affiliation Virus-Cell Interaction Section, HIV Drug Resistance Program, NCI-Frederick, Frederick, Maryland, United States of America

Darren D’Souza

Affiliation Virus-Cell Interaction Section, HIV Drug Resistance Program, NCI-Frederick, Frederick, Maryland, United States of America

Eric O. Freed

Affiliation Virus-Cell Interaction Section, HIV Drug Resistance Program, NCI-Frederick, Frederick, Maryland, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AW EF. Performed the experiments: AW NK KF DD. Analyzed the data: AW EF. Contributed to the writing of the manuscript: AW EF.

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COS cells
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293T cells
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Lysosomes
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HIV-1
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Transfection
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Plasmid construction
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Cell staining
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Immunoprecipitation
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