Oral Supplementation with Non-Absorbable Antibiotics or Curcumin Attenuates Western Diet-Induced Atherosclerosis and Glucose Intolerance in LDLR−/− Mice – Role of Intestinal Permeability and Macrophage Activation

Siddhartha S. Ghosh; Jinghua Bie; Jing Wang; Shobha Ghosh

doi:10.1371/journal.pone.0108577

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Peer-reviewed

Research Article

Oral Supplementation with Non-Absorbable Antibiotics or Curcumin Attenuates Western Diet-Induced Atherosclerosis and Glucose Intolerance in LDLR−/− Mice – Role of Intestinal Permeability and Macrophage Activation

Siddhartha S. Ghosh,

Affiliation Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, Virginia, United States of America
⨯
Jinghua Bie,

Affiliation Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, Virginia, United States of America
⨯
Jing Wang,

Affiliation Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, Virginia, United States of America
⨯
Shobha Ghosh

* E-mail: shobha@vcu.edu

Affiliation Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, Virginia, United States of America
⨯

Oral Supplementation with Non-Absorbable Antibiotics or Curcumin Attenuates Western Diet-Induced Atherosclerosis and Glucose Intolerance in LDLR−/− Mice – Role of Intestinal Permeability and Macrophage Activation

Siddhartha S. Ghosh,
Jinghua Bie,
Jing Wang,
Shobha Ghosh

Published: September 24, 2014
https://doi.org/10.1371/journal.pone.0108577

About the Authors

Siddhartha S. Ghosh

Affiliation Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, Virginia, United States of America

Jinghua Bie

Affiliation Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, Virginia, United States of America

Jing Wang

Affiliation Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, Virginia, United States of America

Shobha Ghosh

* E-mail: shobha@vcu.edu

Affiliation Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, Virginia, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SSG JB JW SG. Performed the experiments: SSG JB JW SG. Analyzed the data: SSG JB JW SG. Contributed reagents/materials/analysis tools: SG. Wrote the paper: SSG SG.

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Gastrointestinal tract
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Diet
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Antibiotics
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Macrophages
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Atherosclerosis
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Gut bacteria
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Permeability
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Glucose intolerance
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