Sequence Specific Binding of Beta Carboline Alkaloid Harmalol with Deoxyribonucleotides: Binding Heterogeneity, Conformational, Thermodynamic and Cytotoxic Aspects

Sarita Sarkar; Prateek Pandya; Kakali Bhadra

doi:10.1371/journal.pone.0108022

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Peer-reviewed

Research Article

Sequence Specific Binding of Beta Carboline Alkaloid Harmalol with Deoxyribonucleotides: Binding Heterogeneity, Conformational, Thermodynamic and Cytotoxic Aspects

Sarita Sarkar,

Current address: Department of Zoology, University of Kalyani, Nadia, West Bengal, India

Affiliation Department of Zoology, University of Kalyani, Nadia, West Bengal, India
⨯
Prateek Pandya,

Current address: Dr. D. S. Kothari PDF No. F.4-2/2006(BSR)/13-557/2011, Department of Chemistry, University of Rajasthan, Jaipur, India,

Affiliation Department of Zoology, University of Kalyani, Nadia, West Bengal, India
⨯
Kakali Bhadra

* E-mail: kakali_bhadra2004@yahoo.com

Affiliation Department of Zoology, University of Kalyani, Nadia, West Bengal, India
⨯

Sequence Specific Binding of Beta Carboline Alkaloid Harmalol with Deoxyribonucleotides: Binding Heterogeneity, Conformational, Thermodynamic and Cytotoxic Aspects

Sarita Sarkar,
Prateek Pandya,
Kakali Bhadra

Published: September 23, 2014
https://doi.org/10.1371/journal.pone.0108022

About the Authors

Sarita Sarkar

Current address: Department of Zoology, University of Kalyani, Nadia, West Bengal, India

Affiliation Department of Zoology, University of Kalyani, Nadia, West Bengal, India

Prateek Pandya

Current address: Dr. D. S. Kothari PDF No. F.4-2/2006(BSR)/13-557/2011, Department of Chemistry, University of Rajasthan, Jaipur, India,

Affiliation Department of Zoology, University of Kalyani, Nadia, West Bengal, India

Kakali Bhadra

* E-mail: kakali_bhadra2004@yahoo.com

Affiliation Department of Zoology, University of Kalyani, Nadia, West Bengal, India

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KB SS. Performed the experiments: SS KB. Analyzed the data: SS KB PP. Contributed reagents/materials/analysis tools: KB. Wrote the paper: KB. Molecular docking/modelling: PP.

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Alkaloids
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Polynucleotides
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Polymers
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Binding analysis
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Fluorescence
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Thermodynamics
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Drug interactions
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Entropy
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