Conservation Weighting Functions Enable Covariance Analyses to Detect Functionally Important Amino Acids

Lucy J. Colwell; Michael P. Brenner; Andrew W. Murray

doi:10.1371/journal.pone.0107723

Loading metrics

Open Access

Peer-reviewed

Research Article

Conservation Weighting Functions Enable Covariance Analyses to Detect Functionally Important Amino Acids

Lucy J. Colwell ,

* E-mail: ljc37@cam.ac.uk

Affiliation University Chemical Laboratory, Cambridge University, Cambridge, United Kingdom
⨯
Michael P. Brenner,

Affiliation School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, United States of America
⨯
Andrew W. Murray

Affiliation FAS Center for Systems Biology, Harvard University, Cambridge, Massachusetts, United States of America
⨯

Conservation Weighting Functions Enable Covariance Analyses to Detect Functionally Important Amino Acids

Lucy J. Colwell,
Michael P. Brenner,
Andrew W. Murray

Published: November 7, 2014
https://doi.org/10.1371/journal.pone.0107723

About the Authors

Lucy J. Colwell

* E-mail: ljc37@cam.ac.uk

Affiliation University Chemical Laboratory, Cambridge University, Cambridge, United Kingdom

Michael P. Brenner

Affiliation School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, United States of America

Andrew W. Murray

Affiliation FAS Center for Systems Biology, Harvard University, Cambridge, Massachusetts, United States of America

Competing Interests

This research was funded in part by Roche Pharmaceuticals. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: LJC MPB AWM. Performed the experiments: LJC MPB AWM. Analyzed the data: LJC MPB AWM. Contributed reagents/materials/analysis tools: LJC MPB AWM. Wrote the paper: LJC MPB AWM.

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Sequence alignment
Is the Subject Area "Sequence alignment" applicable to this article?

Thanks for your feedback.
Algorithms
Is the Subject Area "Algorithms" applicable to this article?

Thanks for your feedback.
Serine proteases
Is the Subject Area "Serine proteases" applicable to this article?

Thanks for your feedback.
Principal component analysis
Is the Subject Area "Principal component analysis" applicable to this article?

Thanks for your feedback.
Crystal structure
Is the Subject Area "Crystal structure" applicable to this article?

Thanks for your feedback.
Cadherins
Is the Subject Area "Cadherins" applicable to this article?

Thanks for your feedback.
Myocardial infarction
Is the Subject Area "Myocardial infarction" applicable to this article?

Thanks for your feedback.
Phylogenetics
Is the Subject Area "Phylogenetics" applicable to this article?

Thanks for your feedback.