About the Authors

Diva Jonatan

Affiliation Division of Developmental Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United States of America

Jason R. Spence

Affiliations Department of Internal Medicine, Division of Gastroenterology, University of Michigan Medical School, Ann Arbor, MI, United States of America, Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI, United States of America, Center for Organogenesis, University of Michigan Medical School, Ann Arbor, MI, United States of America

Anna M. Method

Affiliation Division of Developmental Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United States of America

Matthew Kofron

Affiliation Division of Developmental Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United States of America

Katie Sinagoga

Affiliation Division of Developmental Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United States of America

Leena Haataja

Affiliation Division of Metabolism, Endocrinology, and Diabetes, University of Michigan Medical School, Ann Arbor, MI, United States of America

Peter Arvan

Affiliation Division of Metabolism, Endocrinology, and Diabetes, University of Michigan Medical School, Ann Arbor, MI, United States of America

Gail H. Deutsch

Affiliation Seattle Children’s Hospital, Seattle, WA, United States of America

James M. Wells

James.Wells@cchmc.org

Affiliations Division of Developmental Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United States of America, Division of Endocrinology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Analyzed the data: DJ JMW. Wrote the paper: DJ JMW. Designed all experiments: DJ JMW. Performed most of the experiments: DJ. Assisted in performing the experiments: JMW JRS AMM KS GHD MK. Performed insulin western blots on extracts from isolated islets: PA LH. Assisted in analyzing the data: JRS AMM MK KS LH PA GHD. Reviewed and edited the manuscript: DJ JMW.