About the Authors

Simon G. Anderson

Contributed equally to this work with: Simon G. Anderson, Warwick B. Dunn

Affiliation Institute of Cardiovascular Sciences, Core Technology Facility, The University of Manchester, Manchester, United Kingdom

Warwick B. Dunn

Contributed equally to this work with: Simon G. Anderson, Warwick B. Dunn

Affiliations Manchester Centre for Integrative Systems Biology, Manchester Institute of Biotechnology, The University of Manchester, Manchester, United Kingdom, Centre for Advanced Discovery & Experimental Therapeutics (CADET), Central Manchester NHS Foundation Trust and School of Biomedicine, The University of Manchester, Manchester Academic Health Sciences Centre, Manchester, United Kingdom, School of Biosciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom

Moulinath Banerjee

Affiliation Institute of Cardiovascular Sciences, Core Technology Facility, The University of Manchester, Manchester, United Kingdom

Marie Brown

Affiliation Manchester Centre for Integrative Systems Biology, Manchester Institute of Biotechnology, The University of Manchester, Manchester, United Kingdom

David I. Broadhurst

Affiliations Manchester Centre for Integrative Systems Biology, Manchester Institute of Biotechnology, The University of Manchester, Manchester, United Kingdom, Division of General Internal Medicine, Department of Medicine, 4126A Katz Group Centre for Pharmacy & Health, University of Alberta, Edmonton, Alberta, Canada

Royston Goodacre

Affiliation Manchester Centre for Integrative Systems Biology, Manchester Institute of Biotechnology, The University of Manchester, Manchester, United Kingdom

Garth J. S. Cooper

Affiliations Centre for Advanced Discovery & Experimental Therapeutics (CADET), Central Manchester NHS Foundation Trust and School of Biomedicine, The University of Manchester, Manchester Academic Health Sciences Centre, Manchester, United Kingdom, Maurice Wilkins Centre for Molecular Biodiscovery, Faculty of Science, University of Auckland, Auckland, New Zealand, Department of Pharmacology, University of Oxford, Oxford, United Kingdom

Douglas B. Kell

Affiliation Manchester Centre for Integrative Systems Biology, Manchester Institute of Biotechnology, The University of Manchester, Manchester, United Kingdom

J. Kennedy Cruickshank

kennedy.cruickshank@kcl.ac.uk

Affiliations Institute of Cardiovascular Sciences, Core Technology Facility, The University of Manchester, Manchester, United Kingdom, Diabetes & Nutritional Sciences Division, King's College London, London, United Kingdom

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: WBD SGA DB JKC. Performed the experiments: WBD M. Brown M. Banerjee SGA. Analyzed the data: DB M. Brown SGA WBD. Contributed reagents/materials/analysis tools: DB M. Brown SGA WBD JKC RG GC DBK M. Banerjee. Wrote the paper: WBD SGA M. Brown M. Banerjee DB GC JKC DBK RG. Guarantor of the research: JKC.