About the Authors

Azusa Hara

Affiliation Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Diseases, University of Leuven, Leuven, Belgium

Lutgarde Thijs

Affiliation Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Diseases, University of Leuven, Leuven, Belgium

Kei Asayama

Affiliations Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Diseases, University of Leuven, Leuven, Belgium, Department of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo, Japan

Lotte Jacobs

Affiliation Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Diseases, University of Leuven, Leuven, Belgium

Ji-Guang Wang

Affiliation Center for Epidemiological Studies and Clinical Trials, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China

Jan A. Staessen

jan.staessen@med.kuleuven.be

Affiliations Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Diseases, University of Leuven, Leuven, Belgium, Department of Epidemiology, Maastricht University, Maastricht, the Netherlands

Competing Interests

Bayer AG funded investigator-initiated Syst-Eur trial (1988-1997). The corresponding author owns the data and funding by Bayer does therefore in no way alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: AH LT KA LJ JGW JAS. Analyzed the data: AH LT KA LJ. Wrote the paper: AH JAS. Coordinated the Syst-Eur trial and managed funding: JAS. Constructed the database: LT.