About the Authors
- Angel E. Dago
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Contributed equally to this work with: Angel E. Dago, Asya Stepansky
Affiliation Department of Cell and Molecular Biology, The Scripps Research Institute, La Jolla, California, United States of America
- Asya Stepansky
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Contributed equally to this work with: Angel E. Dago, Asya Stepansky
Affiliations Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, United States of America, Skyline Genomics, Roslyn Heights, New York, United States of America
- Anders Carlsson
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Affiliation Department of Cell and Molecular Biology, The Scripps Research Institute, La Jolla, California, United States of America
- Madelyn Luttgen
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Affiliation Department of Cell and Molecular Biology, The Scripps Research Institute, La Jolla, California, United States of America
- Jude Kendall
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Affiliations Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, United States of America, Skyline Genomics, Roslyn Heights, New York, United States of America
- Timour Baslan
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Affiliations Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, United States of America, Department of Molecular and Cellular Biology, Stony Brook University, Stony Brook, New York, United States of America
- Anand Kolatkar
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Affiliation Department of Cell and Molecular Biology, The Scripps Research Institute, La Jolla, California, United States of America
- Michael Wigler
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Affiliation Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, United States of America
- Kelly Bethel
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Affiliations Department of Cell and Molecular Biology, The Scripps Research Institute, La Jolla, California, United States of America, Department of Pathology, Scripps Clinic, La Jolla, California, United States of America
- Mitchell E. Gross
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Affiliation Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
- James Hicks
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* E-mail: pkuhn@usc.edu (PK); hicks@cshl.edu (JH)
Affiliation Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, United States of America
- Peter Kuhn
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* E-mail: pkuhn@usc.edu (PK); hicks@cshl.edu (JH)
Affiliation Dornsife College of Letters, Arts and Sciences, University of Southern California, Los Angeles, California, United States of America
Competing Interests
The authors have read the journal's policy and have conflicts to disclose. The HD-CTC assay technology described here has been licensed to Epic Sciences. ML, AK, KB and PK have ownership interests in Epic Sciences. AS is an employee of Skyline Genomics, and had a significant role in developing the protocol for isolating DNA from HD-CTC cells and performed the Illumina library preparations. AS did not have any role in design of the experiments or interpretation of the data. JH is a co-founder and shareholder in skyline genomics. AED, AC, JK, TB, MW and MEG and have declared that no competing interests exist.
Author Contributions
Conceived and designed the experiments: AED MEG JH PK. Performed the experiments: AED AS. Analyzed the data: AED AC MEG JK JH PK. Contributed reagents/materials/analysis tools: AS AC ML JK AK TB MW KB. Wrote the paper: AED AC MEG JH PK.