About the Authors

Antonio González-Pérez

Affiliations The Spanish Centre for Pharmacoepidemiologic Research (CEIFE), Madrid, Spain, Andalusian Bioinformatics Research Centre (CAEBi), Seville, Spain

María E. Sáez

Affiliations The Spanish Centre for Pharmacoepidemiologic Research (CEIFE), Madrid, Spain, Andalusian Bioinformatics Research Centre (CAEBi), Seville, Spain

Saga Johansson

Affiliation AstraZeneca R&D, Mölndal, Sweden

Péter Nagy

Affiliation AstraZeneca R&D, Mölndal, Sweden

Luis A. García Rodríguez

lagarcia@ceife.es

Affiliation The Spanish Centre for Pharmacoepidemiologic Research (CEIFE), Madrid, Spain

Competing Interests

Antonio González-Pérez, Luis A. García Rodríguez, and María Eugenia Sáez work for CEIFE, which has received research funding from AstraZeneca R&D, Mölndal, Sweden and Bayer Pharma AG, Berlin, Germany. Luis A. García Rodríguez has received honoraria for serving on scientific advisory boards for AstraZeneca and Bayer. Saga Johansson and Péter Nagy are employees of AstraZeneca R&D, Mölndal, Sweden. Medical writing services from Carolyn Brechin PhD and Stephen Sweet PhD of Oxford PharmaGenesis Ltd, Oxford, UK, were funded by AstraZeneca. The declared potential competing interests do not alter the authors’ adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: AGP MES SJ PN LAGR. Performed the experiments: AGP LAGR MES. Analyzed the data: AGP MES SJ PN LAGR. Wrote the paper: AGP MES SJ PN LAGR.