Oligomerization of Optineurin and Its Oxidative Stress- or E50K Mutation-Driven Covalent Cross-Linking: Possible Relationship with Glaucoma Pathology

Jie Gao; Masafumi Ohtsubo; Yoshihiro Hotta; Shinsei Minoshima

doi:10.1371/journal.pone.0101206

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Open Access

Peer-reviewed

Research Article

Oligomerization of Optineurin and Its Oxidative Stress- or E50K Mutation-Driven Covalent Cross-Linking: Possible Relationship with Glaucoma Pathology

Jie Gao,

Affiliations Department of Photomedical Genomics, Basic Medical Photonics Laboratory, Medical Photonics Research Center, Hamamatsu University School of Medicine, Hamamatsu, Japan, Department of Ophthalmology, Hamamatsu University School of Medicine, Hamamatsu, Japan
⨯
Masafumi Ohtsubo ,

* E-mail: masa.oh@hama-med.ac.jp

Affiliation Department of Photomedical Genomics, Basic Medical Photonics Laboratory, Medical Photonics Research Center, Hamamatsu University School of Medicine, Hamamatsu, Japan
⨯
Yoshihiro Hotta,

Affiliation Department of Ophthalmology, Hamamatsu University School of Medicine, Hamamatsu, Japan
⨯
Shinsei Minoshima

Affiliation Department of Photomedical Genomics, Basic Medical Photonics Laboratory, Medical Photonics Research Center, Hamamatsu University School of Medicine, Hamamatsu, Japan
⨯

Oligomerization of Optineurin and Its Oxidative Stress- or E50K Mutation-Driven Covalent Cross-Linking: Possible Relationship with Glaucoma Pathology

Jie Gao,
Masafumi Ohtsubo,
Yoshihiro Hotta,
Shinsei Minoshima

Published: July 1, 2014
https://doi.org/10.1371/journal.pone.0101206

About the Authors

Jie Gao

Affiliations Department of Photomedical Genomics, Basic Medical Photonics Laboratory, Medical Photonics Research Center, Hamamatsu University School of Medicine, Hamamatsu, Japan, Department of Ophthalmology, Hamamatsu University School of Medicine, Hamamatsu, Japan

Masafumi Ohtsubo

* E-mail: masa.oh@hama-med.ac.jp

Affiliation Department of Photomedical Genomics, Basic Medical Photonics Laboratory, Medical Photonics Research Center, Hamamatsu University School of Medicine, Hamamatsu, Japan

Yoshihiro Hotta

Affiliation Department of Ophthalmology, Hamamatsu University School of Medicine, Hamamatsu, Japan

Shinsei Minoshima

Affiliation Department of Photomedical Genomics, Basic Medical Photonics Laboratory, Medical Photonics Research Center, Hamamatsu University School of Medicine, Hamamatsu, Japan

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JG MO YH SM. Performed the experiments: JG MO. Analyzed the data: JG MO YH SM. Wrote the paper: JG MO YH SM.

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Oligomers
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Immunoprecipitation
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Transfection
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Monomers
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Oxidative stress
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Protein complexes
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Glaucoma
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Transcription factors
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