About the Authors

Michael Frohbergh

Affiliation Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America

Yi Ge

Affiliation Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America

Fanli Meng

Affiliation Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America

Nesrin Karabul

Affiliation Department of Pediatrics, University of Mainz, Mainz, Germany

Alexander Solyom

Affiliations Department of Pediatrics, University of Mainz, Mainz, Germany, Department of Pediatrics, University of Pécs, Pécs, Hungary

Alon Lai

Affiliation Orthopedics, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America

James Iatridis

Affiliation Orthopedics, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America

Edward H. Schuchman

Affiliation Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America

Calogera M. Simonaro

calogera.simonaro@mssm.edu

Affiliation Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America

Competing Interests

A patent has been filed “Anti-TNF therapy for the mucopolysaccharidoses and other lysosomal storage diseases” (PCT/US2012/043369, WO2012177778) by Drs. Simonaro and Schuchman. This patent has not as yet been awarded. This does not alter the authors' adherence to all PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: CMS EHS. Performed the experiments: CMS MF YG FM. Analyzed the data: MF AL JI NK AS EHS CMS. Contributed reagents/materials/analysis tools: CMS EHS JI. Contributed to the writing of the manuscript: MF EHS CMS.