CD4+ T Cell Subset Differentiation and Avidity Setpoint Are Dictated by the Interplay of Cytokine and Antigen Mediated Signals

Erin K. Shiner; Beth C. Holbrook; Martha A. Alexander-Miller

doi:10.1371/journal.pone.0100175

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Open Access

Peer-reviewed

Research Article

CD4⁺ T Cell Subset Differentiation and Avidity Setpoint Are Dictated by the Interplay of Cytokine and Antigen Mediated Signals

Erin K. Shiner,

Affiliation Department of Internal Medicine, Section on Rheumatology and Immunology, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America
⨯
Beth C. Holbrook,

Affiliation Department of Microbiology and Immunology, Section on Rheumatology and Immunology, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America
⨯
Martha A. Alexander-Miller

* E-mail: marthaam@wakehealth.edu

Affiliation Department of Microbiology and Immunology, Section on Rheumatology and Immunology, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America
⨯

CD4⁺ T Cell Subset Differentiation and Avidity Setpoint Are Dictated by the Interplay of Cytokine and Antigen Mediated Signals

Erin K. Shiner,
Beth C. Holbrook,
Martha A. Alexander-Miller

Published: June 18, 2014
https://doi.org/10.1371/journal.pone.0100175

About the Authors

Erin K. Shiner

Affiliation Department of Internal Medicine, Section on Rheumatology and Immunology, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

Beth C. Holbrook

Affiliation Department of Microbiology and Immunology, Section on Rheumatology and Immunology, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

Martha A. Alexander-Miller

* E-mail: marthaam@wakehealth.edu

Affiliation Department of Microbiology and Immunology, Section on Rheumatology and Immunology, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: EKS MAA-M. Performed the experiments: EKS BCH. Analyzed the data: EKS BCH MAA-M. Contributed reagents/materials/analysis tools: EKS BCH MAA-M. Wrote the paper: EKS MAA-M.

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Cytokines
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Cell differentiation
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T cells
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T helper cells
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Signal peptides
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TCR signaling cascade
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Cell cycle and cell division
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Cytotoxic T cells
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