Down-Regulation of mir-221 and mir-222 Restrain Prostate Cancer Cell Proliferation and Migration That Is Partly Mediated by Activation of SIRT1

Xiao Yang; Yingmei Yang; Rong Gan; Lingxu Zhao; Wei Li; Huaibin Zhou; Xiaojuan Wang; Jianxin Lu; Qing H. Meng

doi:10.1371/journal.pone.0098833

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Open Access

Peer-reviewed

Research Article

Down-Regulation of mir-221 and mir-222 Restrain Prostate Cancer Cell Proliferation and Migration That Is Partly Mediated by Activation of SIRT1

Xiao Yang,

Affiliation Wenzhou Medical University School of Laboratory Medicine and Life Sciences, Wenzhou, Zhejiang, China
⨯
Yingmei Yang,

Affiliation Wenzhou Medical University School of Laboratory Medicine and Life Sciences, Wenzhou, Zhejiang, China
⨯
Rong Gan,

Affiliation Wenzhou Medical University School of Laboratory Medicine and Life Sciences, Wenzhou, Zhejiang, China
⨯
Lingxu Zhao,

Affiliation Wenzhou Medical University School of Laboratory Medicine and Life Sciences, Wenzhou, Zhejiang, China
⨯
Wei Li,

Affiliations Wenzhou Medical University School of Laboratory Medicine and Life Sciences, Wenzhou, Zhejiang, China, Key Laboratory of Laboratory Medicine, Ministry of Education, Wenzhou, Zhejiang, China, Zhejiang Provincial Key Laboratory of Medical Genetics, Wenzhou, Zhejiang, China
⨯
Huaibin Zhou,

Affiliations Wenzhou Medical University School of Laboratory Medicine and Life Sciences, Wenzhou, Zhejiang, China, Key Laboratory of Laboratory Medicine, Ministry of Education, Wenzhou, Zhejiang, China, Zhejiang Provincial Key Laboratory of Medical Genetics, Wenzhou, Zhejiang, China
⨯
Xiaojuan Wang,

Affiliations Wenzhou Medical University School of Laboratory Medicine and Life Sciences, Wenzhou, Zhejiang, China, Department of Clinical Laboratory Medicine, Jinhua People's Hospital, Jinhua, Zhejiang, China
⨯
Jianxin Lu,

Affiliations Wenzhou Medical University School of Laboratory Medicine and Life Sciences, Wenzhou, Zhejiang, China, Key Laboratory of Laboratory Medicine, Ministry of Education, Wenzhou, Zhejiang, China, Zhejiang Provincial Key Laboratory of Medical Genetics, Wenzhou, Zhejiang, China
⨯
Qing H. Meng

Affiliation Department of Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯

Down-Regulation of mir-221 and mir-222 Restrain Prostate Cancer Cell Proliferation and Migration That Is Partly Mediated by Activation of SIRT1

Xiao Yang,
Yingmei Yang,
Rong Gan,
Lingxu Zhao,
Wei Li,
Huaibin Zhou,
Xiaojuan Wang,
Jianxin Lu,
Qing H. Meng

Published: June 3, 2014
https://doi.org/10.1371/journal.pone.0098833

About the Authors

Xiao Yang: Affiliation Wenzhou Medical University School of Laboratory Medicine and Life Sciences, Wenzhou, Zhejiang, China
Yingmei Yang: Affiliation Wenzhou Medical University School of Laboratory Medicine and Life Sciences, Wenzhou, Zhejiang, China
Rong Gan: Affiliation Wenzhou Medical University School of Laboratory Medicine and Life Sciences, Wenzhou, Zhejiang, China
Lingxu Zhao: Affiliation Wenzhou Medical University School of Laboratory Medicine and Life Sciences, Wenzhou, Zhejiang, China
Wei Li: Affiliations Wenzhou Medical University School of Laboratory Medicine and Life Sciences, Wenzhou, Zhejiang, China, Key Laboratory of Laboratory Medicine, Ministry of Education, Wenzhou, Zhejiang, China, Zhejiang Provincial Key Laboratory of Medical Genetics, Wenzhou, Zhejiang, China
Huaibin Zhou: Affiliations Wenzhou Medical University School of Laboratory Medicine and Life Sciences, Wenzhou, Zhejiang, China, Key Laboratory of Laboratory Medicine, Ministry of Education, Wenzhou, Zhejiang, China, Zhejiang Provincial Key Laboratory of Medical Genetics, Wenzhou, Zhejiang, China
Xiaojuan Wang: Affiliations Wenzhou Medical University School of Laboratory Medicine and Life Sciences, Wenzhou, Zhejiang, China, Department of Clinical Laboratory Medicine, Jinhua People's Hospital, Jinhua, Zhejiang, China
Jianxin Lu: Affiliations Wenzhou Medical University School of Laboratory Medicine and Life Sciences, Wenzhou, Zhejiang, China, Key Laboratory of Laboratory Medicine, Ministry of Education, Wenzhou, Zhejiang, China, Zhejiang Provincial Key Laboratory of Medical Genetics, Wenzhou, Zhejiang, China
Qing H. Meng: Affiliation Department of Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: QM JL XY. Performed the experiments: XY YY RG LZ WL HZ XW. Wrote the paper: QM JL. Performed data analysis: XY.

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Transfection
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Prostate cancer
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Apoptosis
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Cell proliferation
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Cell migration
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MicroRNAs
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Luciferase
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Cancer cell migration
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