Identification of Nitric Oxide as an Endogenous Inhibitor of 26S Proteasomes in Vascular Endothelial Cells

Hongtao Liu; Shujie Yu; Hua Zhang; Jian Xu

doi:10.1371/journal.pone.0098486

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Open Access

Peer-reviewed

Research Article

Identification of Nitric Oxide as an Endogenous Inhibitor of 26S Proteasomes in Vascular Endothelial Cells

Hongtao Liu,

Affiliation Section of Endocrinology, Department of Medicine and Harold Hamm Oklahoma Diabetes Center, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America
⨯
Shujie Yu,

Affiliation Section of Endocrinology, Department of Medicine and Harold Hamm Oklahoma Diabetes Center, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America
⨯
Hua Zhang,

Affiliation Section of Endocrinology, Department of Medicine and Harold Hamm Oklahoma Diabetes Center, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America
⨯
Jian Xu

* E-mail: jian-xu@ouhsc.edu

Affiliation Section of Endocrinology, Department of Medicine and Harold Hamm Oklahoma Diabetes Center, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America
⨯

Identification of Nitric Oxide as an Endogenous Inhibitor of 26S Proteasomes in Vascular Endothelial Cells

Hongtao Liu,
Shujie Yu,
Hua Zhang,
Jian Xu

Published: May 22, 2014
https://doi.org/10.1371/journal.pone.0098486

About the Authors

Hongtao Liu

Affiliation Section of Endocrinology, Department of Medicine and Harold Hamm Oklahoma Diabetes Center, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America

Shujie Yu

Affiliation Section of Endocrinology, Department of Medicine and Harold Hamm Oklahoma Diabetes Center, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America

Hua Zhang

Affiliation Section of Endocrinology, Department of Medicine and Harold Hamm Oklahoma Diabetes Center, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America

Jian Xu

* E-mail: jian-xu@ouhsc.edu

Affiliation Section of Endocrinology, Department of Medicine and Harold Hamm Oklahoma Diabetes Center, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HL JX. Performed the experiments: HL SY HZ JX. Analyzed the data: HL JX. Wrote the paper: HL JX.

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Proteasomes
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Nitric oxide
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Endothelial cells
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Enzyme-linked immunoassays
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Wheat germ agglutinins
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Immunoprecipitation
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Hyperexpression techniques
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Mouse models
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