The PDZ Domain of the Guanine Nucleotide Exchange Factor PDZGEF Directs Binding to Phosphatidic Acid during Brush Border Formation

Sarah V. Consonni; Patricia M. Brouwer; Eleonora S. van Slobbe; Johannes L. Bos

doi:10.1371/journal.pone.0098253

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Open Access

Peer-reviewed

Research Article

The PDZ Domain of the Guanine Nucleotide Exchange Factor PDZGEF Directs Binding to Phosphatidic Acid during Brush Border Formation

Sarah V. Consonni,

Affiliation Department of Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands
⨯
Patricia M. Brouwer,

Affiliation Department of Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands
⨯
Eleonora S. van Slobbe,

Affiliation Department of Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands
⨯
Johannes L. Bos

* E-mail: j.l.bos@umcutrecht.nl

Affiliation Department of Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands
⨯

The PDZ Domain of the Guanine Nucleotide Exchange Factor PDZGEF Directs Binding to Phosphatidic Acid during Brush Border Formation

Sarah V. Consonni,
Patricia M. Brouwer,
Eleonora S. van Slobbe,
Johannes L. Bos

Published: May 23, 2014
https://doi.org/10.1371/journal.pone.0098253

About the Authors

Sarah V. Consonni

Affiliation Department of Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands

Patricia M. Brouwer

Affiliation Department of Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands

Eleonora S. van Slobbe

Affiliation Department of Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands

Johannes L. Bos

* E-mail: j.l.bos@umcutrecht.nl

Affiliation Department of Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SVC JLB. Performed the experiments: SVC PMB ESvS. Analyzed the data: SVC PMB ESvS JLB. Wrote the paper: SVC JLB.

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Protein domains
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Guanine nucleotide exchange factors
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