Structural Probing of Off-Target G Protein-Coupled Receptor Activities within a Series of Adenosine/Adenine Congeners

Silvia Paoletta; Dilip K. Tosh; Daniela Salvemini; Kenneth A. Jacobson

doi:10.1371/journal.pone.0097858

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Peer-reviewed

Research Article

Structural Probing of Off-Target G Protein-Coupled Receptor Activities within a Series of Adenosine/Adenine Congeners

Silvia Paoletta,

Affiliation Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Dilip K. Tosh,

Affiliation Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Daniela Salvemini,

Affiliation Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America
⨯
Kenneth A. Jacobson

* E-mail: kajacobs@helix.nih.gov

Affiliation Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯

Structural Probing of Off-Target G Protein-Coupled Receptor Activities within a Series of Adenosine/Adenine Congeners

Silvia Paoletta,
Dilip K. Tosh,
Daniela Salvemini,
Kenneth A. Jacobson

Published: May 23, 2014
https://doi.org/10.1371/journal.pone.0097858

About the Authors

Silvia Paoletta

Affiliation Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

Dilip K. Tosh

Daniela Salvemini

Affiliation Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America

Kenneth A. Jacobson

* E-mail: kajacobs@helix.nih.gov

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KAJ SP. Performed the experiments: SP DKT. Analyzed the data: SP KAJ DS. Contributed reagents/materials/analysis tools: DKT. Wrote the paper: SP KAJ DS.

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Adrenergic signal transduction
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G protein coupled receptors
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Drug interactions
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Crystal structure
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Adenosine
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Biogenic amines
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Adenine
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Binding analysis
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