About the Authors

Christopher J. Cardinale

Contributed equally to this work with: Christopher J. Cardinale, Zhi Wei

Affiliation Center for Applied Genomics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Zhi Wei

Contributed equally to this work with: Christopher J. Cardinale, Zhi Wei

Affiliation Department of Computer Science, New Jersey Institute of Technology, Newark, New Jersey, United States of America

Jin Li

Affiliation Center for Applied Genomics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Junfei Zhu

Affiliation Department of Computer Science, New Jersey Institute of Technology, Newark, New Jersey, United States of America

Mengnan Gu

Affiliation Department of Computer Science, New Jersey Institute of Technology, Newark, New Jersey, United States of America

Robert N. Baldassano

Affiliations Division of Gastroenterology, Hepatology, and Nutrition, Children’s Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Struan F. A. Grant

Affiliations Center for Applied Genomics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Hakon Hakonarson

hakonarson@chop.edu

Affiliations Center for Applied Genomics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Competing Interests

Co-author Struan F. A. Grant is a PLOS ONE editorial board member. Zhi Wei is a PLOS ONE academic editor. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: CJC ZW JL RNB HH. Performed the experiments: CJC ZW JL JZ MG. Analyzed the data: CJC ZW JL JZ MG RNB SFAG HH. Contributed reagents/materials/analysis tools: ZW JL JZ MG. Wrote the paper: CJC ZW SFAG HH.