About the Authors

Larissa J. Lee

Contributed equally to this work with: Larissa J. Lee, Elena Ratner

Affiliation Department of Radiation Oncology, Brigham and Women’s Hospital/Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

Elena Ratner

Contributed equally to this work with: Larissa J. Lee, Elena Ratner

Affiliation Department of Gynecologic Oncology, Yale University, New Haven, Connecticut, United States of America

Mohamed Uduman

Affiliation Interdepartmental Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut, United States of America

Kathryn Winter

Affiliation Statistical Center, Radiation Therapy Oncology Group (RTOG), Philadelphia, Pennsylvania, United States of America

Marta Boeke

Affiliation Department of Gynecologic Oncology, Yale University, New Haven, Connecticut, United States of America

Kathryn M. Greven

Affiliation Department of Radiation Oncology, Wake Forest University Baptist Medical Center, Winston-Salem, North Carolina, United States of America

Stephanie King

Affiliation Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America

Thomas W. Burke

Affiliation Department of Gynecologic Oncology and Reproductive Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

Kelly Underhill

Affiliation Department of Radiation Oncology, Benefis Sletten Cancer Institute, Great Falls, Montana, United States of America

Harold Kim

Affiliation Department of Radiation Oncology, Wayne State University Karamanos Cancer Center, Detroit, Michigan, United States of America

Raleigh J. Boulware

Affiliation Radiation Oncology, South Carolina Oncology Associates, Columbia, South Carolina, United States of America

Herbert Yu

Affiliations Department of Chronic Disease and Epidemiology, Yale University, New Haven, Connecticut, United States of America, Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, United States of America

Vinita Parkash

Affiliation Department of Pathology, Yale University, New Haven, Connecticut, United States of America

Lingeng Lu

Affiliation Department of Chronic Disease and Epidemiology, Yale University, New Haven, Connecticut, United States of America

David Gaffney

Affiliation Department of Radiation Oncology, University of Utah Huntsman Cancer Hospital, Salt Lake City, Utah, United States of America

Adam P. Dicker

Affiliation Department of Radiation Oncology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States of America

Joanne Weidhaas

joanne.weidhaas@yale.edu

Affiliation Department of Therapeutic Radiology, Yale University, New Haven, Connecticut, United States of America

Competing Interests

Dr. Weidhaas and Dr. Slack discovered the KRAS-variant, which is patented by Yale University. This patent is called “Genetic Lesion Associated with Cancer”, and the number is 8,221,980. It has been licensed to a company, Mira Dx, that Dr. Slack and Dr. Weidhaas co-founded. Neither Dr. Slack nor Dr. Weidhaas are employed or paid by Mira Dx, but act as unpaid scientific consultants. This does not alter the authors’ adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: DG AD JW. Performed the experiments: ER MB VP. Analyzed the data: MU KW L. Lee. Contributed reagents/materials/analysis tools: HY L. Lu DG AD. Wrote the paper: L. Lee JW. Involved in the inception of the RTOG 9708 and 9905 trials (and are included per RTOG publication policy): KG SK TB KU HK RB.