About the Authors

Shunya Kondo

Affiliation Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland

Alessia Bottos

Affiliation Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland

Jeremy C. Allegood

Affiliation Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine, Richmond, Virginia, United States of America

Regis Masson

Affiliation Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland

Francisca G. Maurer

Affiliation Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland

Christel Genoud

Affiliation Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland

Patrick Kaeser

Affiliations Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland, University of Basel, Basel, Switzerland

Andrea Huwiler

Affiliation Institute of Pharmacology, University of Bern, Bern, Switzerland

Masato Murakami

Affiliation Novartis Institutes for Biomedical Research, Basel, Switzerland

Sarah Spiegel

Affiliation Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine, Richmond, Virginia, United States of America

Nancy E. Hynes

nancy.hynes@fmi.ch

Affiliations Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland, University of Basel, Basel, Switzerland

Competing Interests

One of the authors (Masato Murakami) has the affiliation to a commercial company (Novartis Institutes for Biomedical Research). The authors declare that this does not alter their adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: SK NH. Performed the experiments: SK AB JA RM FM PK. Analyzed the data: SK AB JA CG MM SS. Contributed reagents/materials/analysis tools: SK JA AH SS. Wrote the paper: SK AB NH.