About the Authors

Derek J. Nunez

derek.j.nunez@gsk.com

Affiliation GlaxoSmithKline Research and Development, Research Triangle Park, North Carolina, United States of America

Mark A. Bush

Current address: Nuventra Pharma Sciences, Durham, North Carolina, United States of America

Affiliation GlaxoSmithKline Research and Development, Research Triangle Park, North Carolina, United States of America

David A. Collins

Affiliation GlaxoSmithKline Research and Development, Research Triangle Park, North Carolina, United States of America

Susan L. McMullen

Affiliation GlaxoSmithKline Research and Development, Research Triangle Park, North Carolina, United States of America

Dawn Gillmor

Affiliation GlaxoSmithKline Research and Development, Research Triangle Park, North Carolina, United States of America

Glen Apseloff

Affiliation Ohio State University Clinical Pharmacology Unit, Columbus, Ohio, United States of America

George Atiee

Affiliation Worldwide Clinical Trials, San Antonio, Texas, United States of America

Leonor Corsino

Affiliation Duke University Medical Center, Durham, North Carolina, United States of America

Linda Morrow

Affiliation Profil Institute for Clinical Research, Chula Vista, California, United States of America

Paul L. Feldman

Affiliation GlaxoSmithKline Research and Development, Research Triangle Park, North Carolina, United States of America

Competing Interests

The authors declare the following completing interests: Derek Nunez is an employee of GlaxoSmithKline and was a stock/option holder at the time the studies were conducted. Mark Bush was an employee of GlaxoSmithKline and a stock/option holder at the time the studies were conducted. David Collins is an employee of GlaxoSmithKline and was a stock/option holder at the time the studies were conducted. Susan McMullen is an employee of GlaxoSmithKline and was a stock/option holder at the time the studies were conducted. Dawn Gillmor is an employee of GlaxoSmithKline and was a stock/option holder at the time the studies were conducted. Paul Feldman is an employee of GlaxoSmithKline and was a stock/option holder at the time the studies were conducted. Glen Apseloff is an employee of the Ohio State University and has consulted for GlaxoSmithKline. George Atiee was an employee of ICON Development Solutions at the time these studies were conducted. Leonor Corsino is an employee of the Duke University Medical Center. Linda Morrow is an employee of the Profil Institute for Clinical Research. The studies were sponsored by GlaxoSmithKline R&D. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: DJN MAB DAC SLM DG PLF. Performed the experiments: DJN MAB DAC SLM DG G. Apseloff G. Atiee LC LM. Analyzed the data: DJN MAB DAC PLF. Wrote the paper: DJN MAB DAC. Reviewed drafts and the final version of the manuscript: DJN MAB DAC SLM DG G. Apseloff G. Atiee LC LM PLF.