About the Authors

Lamiae Grimaldi-Bensouda

Lamiae.grimaldi@la-ser.com

Affiliations LA-SER, Paris, France, Pharmacoepidemiology and Infectious Diseases Research Group, Pasteur Institute, Paris, France

Bernard Bégaud

Affiliation INSERM U657, University of Bordeaux Segalen, U657, Bordeaux, France

Michel Rossignol

Affiliations Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Canada, LA-SER Center for Risk Research, Montreal, Canada

Bernard Avouac

Affiliation LA-SER, Paris, France

France Lert

Affiliation INSERM U1018, Center for Epidemiology and Population Health, Villejuif, France

Frederic Rouillon

Affiliation Sainte-Anne Hospital, University of Paris V René Descartes, Paris, France

Jacques Bénichou

Affiliations INSERM U657, Pharmacoepidemiology and evaluation of the impact of health products on human health, Department of Pharmacology, University Victor Segalen Bordeaux 2, Tondu Hospital – Case 41, Bordeaux, France, Department of Biostatistics, University Hospital of Rouen, Rouen, France

Jacques Massol

Affiliation Faculty of Medicine, University of Franche Comté, Besançon, France

Gerard Duru

Affiliation Cyklad Group, Rillieux la Pape, France

Anne-Marie Magnier

Affiliation Faculty of Medicine, University Pierre and Marie Curie, Paris, France

Lucien Abenhaim

Affiliations Department of Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom, LA-SER Europe Limited, London, United Kingdom

Didier Guillemot

Affiliations Pasteur Institute, Paris, France, Faculty of Medicine, University of Paris-Ile de France Ouest, Guyancourt, Paris, France

Competing Interests

The authors have the following interests: LGB, BA and MR are employees of LA-SER, the company conducting the study. LG-B was the recipient of a research fellowship from INSERM (French National Institute of Health and Medical Research) at the time of the study. LA is a stockholder in LA-SER. GD is employed by Cyklad Group. FR and DG received a consulting fee or honorarium from LA-SER for the submitted work. This study was funded by Laboratoires Boiron, France. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: LG-B BB MR BA FL FR JB JM GD A-MM LA DG. Performed the experiments: LG-B. Analyzed the data: LG-B MR DG. Wrote the paper: MR DG. Developed and approved the study protocol and the analyses plan: LG-B BB MR BA FL FR JB JM GD A-MM LA DG. Discussed and interpreted the results: LG-B BB MR BA FL FR JB JM GD A-MM LA DG. Revised the manuscript: LG-B BB MR BA FL FR JB JM GD A-MM LA DG.