About the Authors
- Yan Zhao
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Contributed equally to this work with: Yan Zhao, Ayahisa Watanabe
Affiliation Department of Nuclear Medicine, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
- Ayahisa Watanabe
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Contributed equally to this work with: Yan Zhao, Ayahisa Watanabe
Affiliations Department of Integrated Molecular Imaging, Graduate School of Medicine, Hokkaido University, Sapporo, Japan, Shionogi Innovation Center for Drug Discovery, Shionogi & Co., Ltd., Sapporo, Japan
- Songji Zhao
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Affiliation Department of Tracer Kinetics & Bioanalysis, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
- Tatsuo Kobayashi
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Affiliation Shionogi Innovation Center for Drug Discovery, Shionogi & Co., Ltd., Sapporo, Japan
- Keita Fukao
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Affiliation Shionogi Innovation Center for Drug Discovery, Shionogi & Co., Ltd., Sapporo, Japan
- Yoshikazu Tanaka
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Affiliation Shionogi Innovation Center for Drug Discovery, Shionogi & Co., Ltd., Sapporo, Japan
- Toru Nakano
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Affiliation Shionogi Innovation Center for Drug Discovery, Shionogi & Co., Ltd., Sapporo, Japan
- Tetsuya Yoshida
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Affiliation Shionogi Innovation Center for Drug Discovery, Shionogi & Co., Ltd., Sapporo, Japan
- Hiroshi Takemoto
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Affiliation Shionogi Innovation Center for Drug Discovery, Shionogi & Co., Ltd., Sapporo, Japan
- Nagara Tamaki
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Affiliation Department of Nuclear Medicine, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
- Yuji Kuge
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* E-mail: kuge@ric.hokudai.ac.jp
Affiliations Department of Tracer Kinetics & Bioanalysis, Graduate School of Medicine, Hokkaido University, Sapporo, Japan, Central Institute of Isotope Science, Hokkaido University, Sapporo, Japan
Competing Interests
Prof. Yuji Kuge has received a research grant from Shionogi & Co., Ltd. Drs. Ayahisa Watanabe, Tatsuo Kobayashi, Keita Fukao, Yoshikazu Tanaka, Toru Nakano, Tetsuya Yoshida, and Hiroshi Takemoto have employment at Shionogi & Co., Ltd. All the other authors have reported that they have no relationships relevant to the contents of this paper to disclose. The above interests do not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.
Author Contributions
Conceived and designed the experiments: YK HT SZ YZ AW KF NT TN. Performed the experiments: YZ AW SZ KF TK TY. Analyzed the data: YZ AW SZ KF TK TY YT HT YK. Contributed reagents/materials/analysis tools: SZ NT HT YK. Wrote the manuscript: YZ AW SZ TK KF YT TN TY HT NT YK. Obtained permission for use of recombinant human (rh)-annexin A5 from NCI: YK. Obtained permission for use of irbesartan from Sanofi: HT.