About the Authors

Yan Zhao

Contributed equally to this work with: Yan Zhao, Ayahisa Watanabe

Affiliation Department of Nuclear Medicine, Graduate School of Medicine, Hokkaido University, Sapporo, Japan

Ayahisa Watanabe

Contributed equally to this work with: Yan Zhao, Ayahisa Watanabe

Affiliations Department of Integrated Molecular Imaging, Graduate School of Medicine, Hokkaido University, Sapporo, Japan, Shionogi Innovation Center for Drug Discovery, Shionogi & Co., Ltd., Sapporo, Japan

Songji Zhao

Affiliation Department of Tracer Kinetics & Bioanalysis, Graduate School of Medicine, Hokkaido University, Sapporo, Japan

Tatsuo Kobayashi

Affiliation Shionogi Innovation Center for Drug Discovery, Shionogi & Co., Ltd., Sapporo, Japan

Keita Fukao

Affiliation Shionogi Innovation Center for Drug Discovery, Shionogi & Co., Ltd., Sapporo, Japan

Yoshikazu Tanaka

Affiliation Shionogi Innovation Center for Drug Discovery, Shionogi & Co., Ltd., Sapporo, Japan

Toru Nakano

Affiliation Shionogi Innovation Center for Drug Discovery, Shionogi & Co., Ltd., Sapporo, Japan

Tetsuya Yoshida

Affiliation Shionogi Innovation Center for Drug Discovery, Shionogi & Co., Ltd., Sapporo, Japan

Hiroshi Takemoto

Affiliation Shionogi Innovation Center for Drug Discovery, Shionogi & Co., Ltd., Sapporo, Japan

Nagara Tamaki

Affiliation Department of Nuclear Medicine, Graduate School of Medicine, Hokkaido University, Sapporo, Japan

Yuji Kuge

kuge@ric.hokudai.ac.jp

Affiliations Department of Tracer Kinetics & Bioanalysis, Graduate School of Medicine, Hokkaido University, Sapporo, Japan, Central Institute of Isotope Science, Hokkaido University, Sapporo, Japan

Competing Interests

Prof. Yuji Kuge has received a research grant from Shionogi & Co., Ltd. Drs. Ayahisa Watanabe, Tatsuo Kobayashi, Keita Fukao, Yoshikazu Tanaka, Toru Nakano, Tetsuya Yoshida, and Hiroshi Takemoto have employment at Shionogi & Co., Ltd. All the other authors have reported that they have no relationships relevant to the contents of this paper to disclose. The above interests do not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: YK HT SZ YZ AW KF NT TN. Performed the experiments: YZ AW SZ KF TK TY. Analyzed the data: YZ AW SZ KF TK TY YT HT YK. Contributed reagents/materials/analysis tools: SZ NT HT YK. Wrote the manuscript: YZ AW SZ TK KF YT TN TY HT NT YK. Obtained permission for use of recombinant human (rh)-annexin A5 from NCI: YK. Obtained permission for use of irbesartan from Sanofi: HT.