About the Authors

Sachiko Yamada

Affiliation Department of Nephrology, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, Japan

Jin Nakamura

Affiliation Department of Nephrology, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, Japan

Misako Asada

Affiliation Department of Nephrology, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, Japan

Masayuki Takase

Affiliation Department of Nephrology, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, Japan

Taiji Matsusaka

Affiliation Department of Internal Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan

Taku Iguchi

Affiliation TMK Project, Kyoto University Graduate School of Medicine, Kyoto, Kyoto, Japan

Ryo Yamada

Affiliation Department of Nephrology, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, Japan

Mari Tanaka

Affiliation Department of Nephrology, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, Japan

Atsuko Y. Higashi

Affiliation Deaprtment of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, Japan

Tomohiko Okuda

Affiliation Department of Nephrology, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, Japan

Nariaki Asada

Affiliation Department of Nephrology, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, Japan

Atsushi Fukatsu

Affiliation Yachiyo Hospital, Anjyo, Aichi, Japan

Hiroshi Kawachi

Affiliation Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Niigata, Japan

Daniel Graf

Affiliation Institute of Oral Biology, Faculty of Medicine, University of Zurich, Zurich, Switzerland

Eri Muso

Affiliation Department of Nephrology and Dialysis, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Osaka, Osaka, Japan

Toru Kita

Affiliation Kobe City Medical Center General Hospital, Kobe, Hyogo, Japan

Takeshi Kimura

Affiliation Deaprtment of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, Japan

Ira Pastan

Affiliation Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

Aris N. Economides

Affiliation Regeneron Pharmaceuticals, Inc., Tarrytown, New York, United States of America

Motoko Yanagita

motoy@kuhp.kyoto-u.ac.jp

Affiliation Department of Nephrology, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, Japan

Competing Interests

Aris N. Economides is employed by Regeneron Pharmaceuticals, Inc. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: MY. Performed the experiments: SY JN MA M. Takase TM TI RY NA. Analyzed the data: SY M. Tanaka AYH. Contributed reagents/materials/analysis tools: TM TO AF HK IP DG ANE EM T. Kimura T. Kita. Wrote the paper: SY MY.